Departement of General Surgery, Alborz University of Medical Science, Alborz, Iran.
Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran.
Fundam Clin Pharmacol. 2022 Oct;36(5):777-789. doi: 10.1111/fcp.12780. Epub 2022 Apr 20.
Hematological malignancies including leukemia, multiple myeloma, and lymphoma are known as leading causes of death around the world. Despite all developments in cancer management, current therapeutic methods are still relatively inefficient, leading to the heavy financial burdens for public health systems. Strategic attempts in clinical practice must be based on three serious goals including (1) increasing the efficacy of treatments and decreasing their side-effects; (2) decreasing financial price of treatments and related morbidity and mortality rates; and (3) improving life quality and survival of affected patients. Melatonin, a multipotential neurohormone mainly secreted by the pineal gland, has recently been shown to play essential roles in the treatment of various human diseases. Moreover, it possesses anticancer impacts and acts through regulation of underlying cellular and molecular mechanisms. In this article, we review mechanistic roles and beneficial effects of melatonin against hematological cancers, especially lymphoma.
血液系统恶性肿瘤包括白血病、多发性骨髓瘤和淋巴瘤，是目前全球主要的致死病因。尽管在癌症管理方面取得了所有进展，但目前的治疗方法仍然相对低效，给公共卫生系统带来了沉重的经济负担。临床实践中的战略尝试必须基于三个严峻目标，包括（1）提高治疗效果，减少副作用；（2）降低治疗费用和相关发病率及死亡率；（3）提高受影响患者的生活质量和生存率。褪黑素是一种主要由松果体分泌的多功能神经激素，最近已被证明在治疗各种人类疾病方面发挥着重要作用。此外，它具有抗癌作用，并通过调节潜在的细胞和分子机制发挥作用。在本文中，我们综述了褪黑素对血液系统恶性肿瘤（尤其是淋巴瘤）的作用机制和有益作用。
