Pourhanifeh Mohammad Hossein, Kamali Mahboobeh, Mehrzadi Saeed, Hosseinzadeh Azam
Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran.
Central Library, Iran University of Medical Sciences, Tehran, Iran.
Mol Biol Rep. 2021 May;48(5):4659-4665. doi: 10.1007/s11033-021-06439-1. Epub 2021 Jun 1.
Neuroblastoma is a deadly and serious malignancy among children. Although many developments have been occurred for the treatment of this disease, the rate of mortality is still high. Therefore, it is necessary to search for novel complementary and alternative therapies. Melatonin, a hormone secreted from pineal gland, is a multifunctional agent having anticancer potentials. Recently, several investigations have been conducted indicating melatonin effects against neuroblastoma. In this paper, we summarize current evidence on anti-neuroblastoma effects of melatonin based on cellular pathways.
神经母细胞瘤是儿童中一种致命且严重的恶性肿瘤。尽管在这种疾病的治疗方面已经取得了许多进展，但死亡率仍然很高。因此，有必要寻找新的补充和替代疗法。褪黑素是一种由松果体分泌的激素，是一种具有抗癌潜力的多功能物质。最近，已经进行了几项研究，表明褪黑素对神经母细胞瘤有作用。在本文中，我们基于细胞途径总结了目前关于褪黑素抗神经母细胞瘤作用的证据。
