Department of Cardiology, Memorial Ankara Hospital, Ankara, Turkey.
Department of Dermatology, Faculty of Medicine, Ufuk University, Ankara, Turkey.
J Cosmet Dermatol. 2022 Aug;21(8):3598-3602. doi: 10.1111/jocd.14969. Epub 2022 Apr 12.
Psoriasis is a chronic, inflammatory skin disease that is common in both adult and childhood. Patients with psoriasis are at significant risk for the development of many comorbid conditions, including cardiovascular diseases.
We aimed to investigate the cardiovascular risk status and serum lipid parameters in patients with psoriasis and to determine the risk of cardiovascular disease by atherogenic indices obtained accordingly.
This retrospective case-control study was conducted with a total of 142 individuals, 72 patients with psoriasis vulgaris and 70 healthy volunteers over the age of 18 who were admitted to the dermatology outpatient clinic. Demographic information and laboratory values were retrieved from the hospital database. Afterward, atherogenic indexes such as Atherogenic index of plasma (AIP), Castelli Risk Index I and II (CRI-I and II), and Atherogenic coefficient (AC) were calculated.
There was a significant difference in lipid profile between the psoriasis patients and the control group. In patients with psoriasis, triglyceride level (140.09 ± 71.20 mg/dl vs. 116.10 ± 63.95, p = 0.037) was higher, while HDL level (44.34 ± 11.77 mg/dl vs. 50.31 ± 11.62, p = 0.003) was lower. Regarding atherogenic indices; AIP (0.10 ± 0.24 vs. -0.04 ± 0.27, p = 0.001), CRI-I (4.63 ± 1.40 vs. 3.94 ± 1.02, p = 0.001), CRI-II (2.98 ± 1.01 vs. 2.61 ± 0.82, p = 0.019) and AC (3.63 ± 1.40 vs.. 2.94 ± 1.02, p = 0.001) were significantly higher in patients with psoriasis.
Our study shows that patients with psoriasis have higher pro-atherogenic lipid profile and atherogenic indexes at a high risk level. Patients with psoriasis have an increased risk of cardiovascular diseases.
银屑病是一种常见于成人和儿童的慢性炎症性皮肤病。银屑病患者发生多种合并症的风险显著增加，包括心血管疾病。
我们旨在研究银屑病患者的心血管风险状况和血清脂质参数，并通过相应获得的致动脉粥样硬化指数来确定心血管疾病的风险。
本回顾性病例对照研究共纳入 142 名个体，其中 72 名寻常型银屑病患者和 70 名年龄在 18 岁以上的健康志愿者，均在皮肤科门诊就诊。从医院数据库中检索人口统计学信息和实验室值。此后，计算了致动脉粥样硬化指数，如血浆致动脉粥样硬化指数（AIP）、卡斯特利风险指数 I 和 II（CRI-I 和 II）和致动脉粥样硬化系数（AC）。
银屑病患者与对照组之间的血脂谱存在显著差异。银屑病患者的甘油三酯水平（140.09±71.20mg/dl vs. 116.10±63.95mg/dl，p=0.037）较高，而高密度脂蛋白水平（44.34±11.77mg/dl vs. 50.31±11.62mg/dl，p=0.003）较低。关于致动脉粥样硬化指数；AIP（0.10±0.24 vs. -0.04±0.27，p=0.001）、CRI-I（4.63±1.40 vs. 3.94±1.02，p=0.001）、CRI-II（2.98±1.01 vs. 2.61±0.82，p=0.019）和 AC（3.63±1.40 vs. 2.94±1.02，p=0.001）在银屑病患者中显著升高。
我们的研究表明，银屑病患者具有更高的促动脉粥样硬化脂质谱和高风险水平的致动脉粥样硬化指数。银屑病患者发生心血管疾病的风险增加。
