Division of Transplant and Hepatobiliary Surgery, Henry Ford Hospital, Detroit, Michigan.
Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan.
Am J Transplant. 2022 Sep;22(9):2261-2264. doi: 10.1111/ajt.17053. Epub 2022 Apr 18.
Combined liver and lung transplantation (CLLT) is indicated in patients with both end-stage liver and lung disease. Ex-situ normothermic machine perfusion (NMP) has been previously used for extended normothermic lung preservation in CLLT. We aim to describe our single-center experience using ex-situ NMP for extended normothermic liver preservation in CLLT. Four CLLTs were performed from 2019 to 2020 with the lung transplanted first for all patients. Median ex-situ pump time for the liver was 413 min (IQR 400-424). Over a median follow-up of 15 months (IQR 14-19), all patients were alive and doing well. Normothermic extended liver preservation is a safe method to allow prolonged cold ischemia using normothermic perfusion of the liver during CLLT.
肝肺联合移植（CLLT）适用于终末期肝肺疾病患者。离体常温机器灌注（NMP）先前已用于 CLLT 中延长常温肺保存。我们旨在描述我们使用离体 NMP 进行 CLLT 中延长常温肝保存的单中心经验。2019 年至 2020 年期间进行了 4 例 CLLT，所有患者均首先移植肺。肝体外泵时间中位数为 413 分钟（IQR 400-424）。中位随访 15 个月（IQR 14-19）后，所有患者均存活且状况良好。常温延长肝保存是一种安全的方法，可以在 CLLT 期间通过常温灌注肝脏来延长冷缺血时间。
