Behavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Department of Pediatrics, Biostatistics, Epidemiology, and Data Management Core, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Am J Addict. 2022 May;31(3):256-260. doi: 10.1111/ajad.13268. Epub 2022 Apr 6.
More information is needed about comorbidities among patients receiving buprenorphine maintenance treatment and their relationship with retention. METHODS: Retrospective electronic health record data over a 5-year period from primary care patients receiving buprenorphine for the treatment of opioid use disorder were examined (N = 899). The present analysis determined the prevalence of comorbidities and examined associations with treatment retention as defined by cumulative duration of buprenorphine prescription. RESULTS: Tobacco use and comorbidities including hypertension were prevalent but did not predict retention according to survival analyses controlling for demographic characteristics. Retention was poorer among patients testing positive for cocaine (HR = 1.38, 95% CI: 1.09-1.74, p = .007) and patients with hepatitis C virus (HR = 1.17, 95% CI: 1.01-1.37, p = .04). CONCLUSION AND SCIENTIFIC SIGNIFICANCE: This study provides new knowledge of previously unexamined associations between comorbidities (e.g., hypertension) and buprenorphine treatment retention. The robust association between cocaine use and poorer buprenorphine retention serves to resolve prior conflicting data in the literature.
需要更多关于接受丁丙诺啡维持治疗的患者的合并症及其与保留率的关系的信息。方法：对接受丁丙诺啡治疗阿片类药物使用障碍的初级保健患者的 5 年电子健康记录数据进行回顾性分析（N=899）。本分析确定了合并症的患病率，并根据丁丙诺啡处方累积持续时间来检查与治疗保留率的关联。结果：烟草使用和包括高血压在内的合并症很普遍，但生存分析控制了人口统计学特征后，并未预测保留率。可卡因检测阳性的患者（HR=1.38，95%CI：1.09-1.74，p=0.007）和丙型肝炎病毒（HR=1.17，95%CI：1.01-1.37，p=0.04）的保留率较差。结论和科学意义：本研究提供了关于合并症（如高血压）与丁丙诺啡治疗保留率之间以前未检查过的关联的新知识。可卡因使用与丁丙诺啡保留率降低之间的紧密关联解决了文献中先前存在的相互矛盾的数据。
