Ammons M A, Bauling P C, Weil R
Transplant Proc. 1986 Dec;18(6):1868-70.
Pneumatosis cystoides intestinalis has been detected in 3/103 kidney transplant patients (3%) treated with CsA and prednisone, in contrast to less than 1% of kidney transplant patients treated with Aza and prednisone. In these three patients, the diagnosis of PCI was made by plain x-rays, 10 to 25 days after transplantation. PCI may be more likely to occur in patients with CsA trough blood levels above the recommended therapeutic range. There was associated pneumoperitoneum in all three patients, but none were subjected to exploratory laparotomy. PCI and associated pneumoperitoneum were not associated with adverse effects in any of our three patients. Antibiotics and exploratory laparotomy appear to be unnecessary.
在接受环孢素A（CsA）和泼尼松治疗的103例肾移植患者中，有3例（3%）检测到肠壁囊样积气，相比之下，接受硫唑嘌呤（Aza）和泼尼松治疗的肾移植患者中这一比例不到1%。在这3例患者中，移植后10至25天通过腹部平片做出了肠壁囊样积气的诊断。CsA谷血水平高于推荐治疗范围的患者可能更易发生肠壁囊样积气。所有3例患者均伴有气腹，但均未接受剖腹探查术。在我们的3例患者中，肠壁囊样积气和气腹均未产生不良反应。抗生素和剖腹探查术似乎没有必要。
