State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, College of Agronomy, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Roy J. Carver Department of Biochemistry, Biophysics & Molecular Biology, Iowa State University, Ames, Iowa 50011, United States.
Org Lett. 2022 Apr 15;24(14):2646-2649. doi: 10.1021/acs.orglett.2c00680. Epub 2022 Apr 6.
A barley diterpene synthase (HvKSL4) was found to produce (14)-cleistantha-8,12-diene (). Formation of the nearly planar cyclohexa-1,4-diene configuration leaves the ring poised for aromatization, but necessitates a deceptively complicated series of rearrangements steered through a complex energetic landscape, as elucidated here through quantum chemical calculations and labeling studies.
大麦二萜合酶（HvKSL4）被发现可以合成（14）-Cleistantha-8,12-二烯（）。几乎呈平面的环己-1,4-二烯构型的形成使环处于芳构化的位置，但需要通过复杂的能量景观进行一系列复杂的重排，正如通过量子化学计算和标记研究在这里阐明的那样。
