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癌症干细胞:从造血干细胞到白血病干细胞的冒险之旅。

Cancer stem cells: The adventurous journey from hematopoietic to leukemic stem cells.

机构信息

Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), 69120 Heidelberg, Germany; Division of Stem Cells and Cancer, Deutsches Krebsforschungszentrum (DKFZ), 69120 Heidelberg, Germany; German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.

Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), 69120 Heidelberg, Germany; Division of Stem Cells and Cancer, Deutsches Krebsforschungszentrum (DKFZ), 69120 Heidelberg, Germany; German Cancer Consortium (DKTK), 69120 Heidelberg, Germany; Berlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin, 10117 Berlin, Germany; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Institute for Medical Systems Biology (BIMSB), 10115 Berlin, Germany; Department of Hematology, Oncology and Cancer Immunology, Charité - Universitätsmedizin Berlin, 10115 Berlin, Germany.

出版信息

Cell. 2022 Apr 14;185(8):1266-1270. doi: 10.1016/j.cell.2022.03.025. Epub 2022 Apr 5.

Abstract

This year's Gairdner Foundation Award for Biomedical Research is awarded to John Dick for the discovery of leukemic stem cells and the hierarchical organization of acute myeloid leukemias. His work laid the foundation for the cancer stem cell model with numerous clinical implications for hematopoietic malignancies and solid tumors.

摘要

今年的盖尔德纳基金会生物医学研究奖授予约翰·迪克,以表彰他发现白血病干细胞和急性髓系白血病的层级组织。他的工作为癌症干细胞模型奠定了基础,对造血恶性肿瘤和实体肿瘤具有众多临床意义。

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