Benagiano Giuseppe, Guo Sun-Wei
Faculty of Medicine and Dentistry, Sapienza University of Rome Rome Italy.
Shanghai Obstetrics and Gynecology Hospital Fudan University Shanghai China.
Reprod Med Biol. 2022 Jan 21;21(1):e12438. doi: 10.1002/rmb2.12438. eCollection 2022 Jan-Dec.
To analyze the characteristics of the ovarian endometrioma (OE) across the life span of a woman. In the past, the OE has traditionally been viewed as a single, monolithic disease. Today, there are emerging data indicating that OE phenotypes differ according to the age of the woman.
A narrative review of original articles on OE indexed by PubMed.
When appearing in , OE may be the consequence of endometrial cells retrogradely shed with neonatal uterine bleeding. The - variant, manifesting itself during full adolescence, is singularly frequent in the presence of vaginal or uterine outflow obstructive anomalies. The typical and most frequent is characterized by increasing fibrosis and a tendency to progress; its mere presence exerts a detrimental effect on the surrounding healthy ovarian tissue. In , an old lesion may be reactivated in the presence of exogenous or endogenous estrogens, or even be produced ; rarely, it can spread to a variety of organs and structures and even degenerate causing malignancies.
Given the existence of these variants, it is important to agree on management guidelines that take into consideration these different phenotypes.
分析女性一生中卵巢子宫内膜异位囊肿（OE）的特征。过去，OE传统上被视为一种单一的整体疾病。如今，有新数据表明，OE的表型因女性年龄而异。
对PubMed索引的关于OE的原始文章进行叙述性综述。
OE出现在[此处信息缺失]时，可能是新生儿子宫出血时逆行脱落的子宫内膜细胞所致。[此处信息缺失]变体在青春期完全显现，在存在阴道或子宫流出道梗阻性异常时尤为常见。典型且最常见的[此处信息缺失]的特征是纤维化增加且有进展倾向；其存在本身就会对周围健康的卵巢组织产生有害影响。在[此处信息缺失]时，旧病灶在外源性或内源性雌激素存在的情况下可能会重新激活，甚至产生[此处信息缺失]；很少情况下，它会扩散到各种器官和结构，甚至发生退变导致恶性肿瘤。
鉴于这些变体的存在，就考虑到这些不同表型的管理指南达成一致很重要。
