Academic Unit of Obstetrics and Gynecology, IRCCS Ospedale Policlinico San Martino, Largo R. Benzi 10, 16132 Genoa, Italy.
Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genova, 16126 Genoa, Italy.
Medicina (Kaunas). 2019 Aug 30;55(9):550. doi: 10.3390/medicina55090550.
: Previous studies did not draw a definitive conclusion about the influence of the role of deep endometriosis (DE) and ovarian endometrioma (OE) as risk factor for developing adverse perinatal outcomes in patients affected by endometriosis. This study aimed to investigate if adverse fetal and maternal outcomes, and in particular the incidence of small for gestational age (SGA) infants, are different in pregnant women with OE versus pregnant women with DE without OE. : This study was based on a retrospective analysis of a database collected prospectively. The population included in the study was divided into three groups: patients with OE, patients with DE without concomitant OE, and patients without endometriosis (controls). The controls were matched on the basis of age and parity. Demographic data at baseline and pregnancy outcomes were recorded. : There was no statistically significant difference in first trimester levels of PAPP-A, first and mid-pregnancy trimester mean Uterine Artery Doppler pulsatile index, estimated fetal weight centile, and SGA fetuses' prevalence for patients with OE, and those with DE without OE in comparison to health women; moreover, there was no statistically significant difference with regard to SGA birth prevalence, prevalence of preeclampsia, and five-minute Apgar score between these three groups. : The specific presence of OE or DE in pregnant women does not seem to be associated with an increased risk of delivering an SGA infant. These data seem to suggest that patients with endometriosis should be treated in pregnancy as the general population, thus not needing a closer monitoring.
: 先前的研究并未就深部子宫内膜异位症 (DE) 和卵巢子宫内膜异位囊肿 (OE) 作为子宫内膜异位症患者发生不良围产结局的危险因素得出明确结论。本研究旨在探讨 OE 与无 OE 的 DE 患者相比，是否会对胎儿和产妇产生不良影响，特别是是否会增加小于胎龄儿 (SGA) 的发生率。: 本研究基于前瞻性收集的数据库进行回顾性分析。研究人群分为三组：OE 患者、无 OE 的 DE 患者和无子宫内膜异位症的患者（对照组）。对照组按年龄和产次匹配。记录基线时的人口统计学数据和妊娠结局。: OE 患者、无 OE 的 DE 患者与健康女性相比，其妊娠早期 PAPP-A 水平、第一和中期妊娠子宫动脉多普勒搏动指数均值、估计胎儿体重百分位数以及 SGA 胎儿的发生率均无统计学差异；此外，三组之间 SGA 出生发生率、子痫前期发生率和 5 分钟 Apgar 评分也无统计学差异。: 在孕妇中，OE 或 DE 的具体存在似乎与 SGA 婴儿的分娩风险增加无关。这些数据表明，子宫内膜异位症患者在怀孕期间应像普通人群一样接受治疗，因此不需要更密切的监测。
