Department of Pharmacology and Toxicology, Institute of Pharmacy, Freie Universität Berlin, Germany.
Front Immunol. 2022 Mar 21;13:861351. doi: 10.3389/fimmu.2022.861351. eCollection 2022.
Ten-eleven translocation proteins (TET1-3) are dioxygenases that oxidize 5-methyldeoxycytosine, thus taking part in passive and active demethylation. TETs have shown to be involved in immune cell development, affecting from self-renewal of stem cells and lineage commitment to terminal differentiation. In fact, dysfunction of TET proteins have been vastly associated with both myeloid and lymphoid leukemias. Recently, there has been accumulating evidence suggesting that TETs regulate immune cell function during innate and adaptive immune responses, thereby modulating inflammation. In this work, we pursue to review the current and recent evidence on the mechanistic aspects by which TETs regulate immune cell maturation and function. We will also discuss the complex interplay of TET expression and activity by several factors to modulate a multitude of inflammatory processes. Thus, modulating TET enzymes could be a novel pharmacological approach to target inflammation-related diseases and myeloid and lymphoid leukemias, when their activity is dysregulated.
十号十一号转位蛋白（TET1-3）是双加氧酶，可氧化 5-甲基脱氧胞嘧啶，从而参与被动和主动去甲基化。TET 已被证明参与免疫细胞的发育，影响从干细胞的自我更新和谱系承诺到终末分化。事实上，TET 蛋白的功能障碍与髓系和淋巴白血病都有很大关系。最近，越来越多的证据表明，TET 调节先天和适应性免疫反应期间免疫细胞的功能，从而调节炎症。在这项工作中，我们旨在综述目前和最近的证据，说明 TET 调节免疫细胞成熟和功能的机制方面。我们还将讨论多种因素对 TET 表达和活性的复杂相互作用，以调节多种炎症过程。因此，当 TET 酶的活性失调时，调节 TET 酶可能是一种针对炎症相关疾病和髓系和淋巴白血病的新的药理学方法。
