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食蟹猴运动行为与年龄相关性椎间盘退变之间的相关性

Correlation between motor behavior and age-related intervertebral disc degeneration in cynomolgus monkeys.

作者信息

Wang Jianmin, Zhu Peixuan, Pan Ximin, Yang Jun, Wang Shijun, Wang Wentao, Li Baoliang, Zhu Zhengya, Tang Tao, Chen Dafu, Gao Manman, Zhou Zhiyu

机构信息

Department of Orthopedic Surgery The Seventh Affiliated Hospital of Sun Yat-sen University Shenzhen China.

International Medical Center Foresea Life Insurance Guangzhou General Hospital Guangzhou China.

出版信息

JOR Spine. 2022 Jan 1;5(1):e1183. doi: 10.1002/jsp2.1183. eCollection 2022 Mar.

DOI:10.1002/jsp2.1183
PMID:35386757
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8966873/
Abstract

BACKGROUND

The motor behavior in patients with lumbar intervertebral disc degeneration (IDD) and animal models should be changed due to pain. However, there does not seem to be a strong correlation between IDD and motor behavior. Therefore, it is necessary to understand the correlation between motor behavior and age-related IDD.

METHODS

Twenty-one healthy male cynomolgus monkeys () distributed across the age range were included in this study. The experimental animals were divided into two groups: caged group (n = 14) and free-range group (n = 7). The data of IDD and motor behavior were obtained through magnetic resonance imaging (MRI) and PrimateScan Automatic Behavior Analysis System. More than 20 basic motor behaviors could be recorded and quantified, and then reclassified into 9 combined categories. We defined the sum of the duration of activity-related combined categories as the total duration of activity in 3 hours. The activity zone of the cynomolgus monkeys in the cage could be divided into top and bottom zones. Analyze the correlation between motor behavior and IDD.

RESULTS

Age was correlated with both Pfirrmann grades ( = .700;  < .001) and T2 values ( = -.369;  < .001). The T2 value in the caged group was 45.97 ± 8.35 ms, which was significantly lower than the 55.90 ± 8.73 ms in the free-range group ( < .001). The mean T2 values were positively correlated with hanging duration ( = .548,  < .05), the total duration of activity ( = .496,  < .05), and top zone duration ( = .541,  < .05).

CONCLUSIONS

There is an interactional relationship between IDD and motor behavior. Motor behavior could be used as one of the diagnostic indicators of IDD. It could also be used to infer the presence or extent of IDD in animal models. Avoiding a sedentary lifestyle and engaging in exercise in daily life could alleviate IDD.

摘要

背景

腰椎间盘退变（IDD）患者和动物模型的运动行为应因疼痛而改变。然而，IDD与运动行为之间似乎没有很强的相关性。因此，有必要了解运动行为与年龄相关性IDD之间的关系。

方法

本研究纳入了21只年龄分布在一定范围内的健康雄性食蟹猴。实验动物分为两组：笼养组（n = 14）和放养组（n = 7）。通过磁共振成像（MRI）和灵长类动物自动行为分析系统获得IDD和运动行为的数据。可以记录和量化20多种基本运动行为，然后重新分类为9个组合类别。我们将与活动相关的组合类别的持续时间总和定义为3小时内的活动总持续时间。笼中食蟹猴的活动区域可分为顶部和底部区域。分析运动行为与IDD之间的相关性。

结果

年龄与Pfirrmann分级（r = 0.700；P < 0.001）和T2值（r = -0.369；P < 0.001）均相关。笼养组的T2值为45.97±8.35毫秒，显著低于放养组的55.90±8.73毫秒（P < 0.001）。平均T2值与悬挂持续时间（r = 0.548，P < 0.05）、活动总持续时间（r = 0.496，P < 0.05）和顶部区域持续时间（r = 0.541，P < 0.05）呈正相关。

结论

IDD与运动行为之间存在相互作用关系。运动行为可作为IDD的诊断指标之一。它还可用于推断动物模型中IDD的存在或程度。避免久坐的生活方式并在日常生活中进行锻炼可减轻IDD。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0acc/8966873/1352e9764212/JSP2-5-e1183-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0acc/8966873/a649bdfde574/JSP2-5-e1183-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0acc/8966873/38d92aec6f27/JSP2-5-e1183-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0acc/8966873/18064215d369/JSP2-5-e1183-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0acc/8966873/fd896f880e87/JSP2-5-e1183-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0acc/8966873/f40436edc273/JSP2-5-e1183-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0acc/8966873/1352e9764212/JSP2-5-e1183-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0acc/8966873/a649bdfde574/JSP2-5-e1183-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0acc/8966873/38d92aec6f27/JSP2-5-e1183-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0acc/8966873/18064215d369/JSP2-5-e1183-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0acc/8966873/fd896f880e87/JSP2-5-e1183-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0acc/8966873/f40436edc273/JSP2-5-e1183-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0acc/8966873/1352e9764212/JSP2-5-e1183-g003.jpg

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