Haut Donahue T L, Narez G E, Powers M, Dejardin L M, Wei F, Haut R C
Department of Biomedical Engineering, University of Memphis, Memphis, TN, United States.
Department of Biomedical Engineering, University of Massachusetts Amherst, Amherst, MA, United States.
Front Bioeng Biotechnol. 2022 Mar 21;10:835730. doi: 10.3389/fbioe.2022.835730. eCollection 2022.
Post-traumatic osteoarthritis (PTOA) is a debilitating disease that is a result of a breakdown of knee joint tissues following traumatic impact. The interplay of how these tissues influence each other has received little attention because of complex interactions. This study was designed to correlate the degeneration of the menisci, cartilage and subchondral bone following an acute traumatic event that resulted in anterior cruciate ligament (ACL) and medial meniscus tears. We used a well-defined impact injury animal model that ruptures the ACL and tears the menisci. Subsequently, the knee joints underwent ACL reconstruction and morphological analyses were performed on the menisci, cartilage and subchondral bone at 1-, 3- and 6-months following injury. The results showed that the morphological scores of the medial and lateral menisci worsened with time, as did the tibial plateau and femoral condyle articular cartilage scores. The medial meniscus was significantly correlated to the medial tibial subchondral bone at 1 month ( = 0.01), and to the medial tibial cartilage at 3 months ( = 0.04). There was only one significant correlation in the lateral hemijoint, i.e., the lateral tibial cartilage to the lateral tibial subchondral bone at 6 months ( = 0.05). These data may suggest that, following trauma, the observed medial meniscal damage should be treated acutely by means other than a full or partial meniscectomy, since that procedure may have been the primary cause of degenerative changes in the underlying cartilage and subchondral bone. In addition to potentially treating meniscal damage differently, improvements could be made in optimizing treatment of acute knee trauma.
创伤后骨关节炎（PTOA）是一种使人衰弱的疾病，它是创伤性冲击后膝关节组织受损的结果。由于这些组织之间存在复杂的相互作用，它们之间如何相互影响的问题很少受到关注。本研究旨在关联急性创伤事件（导致前交叉韧带（ACL）和内侧半月板撕裂）后半月板、软骨和软骨下骨的退变情况。我们使用了一种定义明确的冲击损伤动物模型，该模型会导致ACL断裂和半月板撕裂。随后，对膝关节进行ACL重建，并在损伤后1个月、3个月和6个月对半月板、软骨和软骨下骨进行形态学分析。结果显示，内侧和外侧半月板的形态学评分随时间恶化，胫骨平台和股骨髁关节软骨评分也是如此。内侧半月板在1个月时与胫骨内侧软骨下骨显著相关（ = 0.01），在3个月时与胫骨内侧软骨显著相关（ = 0.04）。外侧半关节只有一个显著相关性，即6个月时外侧胫骨软骨与外侧胫骨软骨下骨显著相关（ = 0.05）。这些数据可能表明，创伤后，观察到的内侧半月板损伤不应通过半月板全切或部分切除等方式进行急性治疗，因为该手术可能是其下方软骨和软骨下骨退变改变的主要原因。除了可能以不同方式治疗半月板损伤外，在优化急性膝关节创伤的治疗方面也可以取得进展。
