由低共熔混合物合成5-未取代的二氢嘧啶酮-4-羧酸酯
Synthesis of 5-unsubstituted dihydropyrimidinone-4-carboxylates from deep eutectic mixtures.
作者信息
Gore Sangram, Baskaran Sundarababu, König Burkhard
机构信息
Department of Chemistry, Indian Institute of Technology Madras, Chennai 600036, India.
Institut für Organische Chemie, Universität Regensburg, Universitätsstraße 31, D-93040 Regensburg, Germany.
出版信息
Beilstein J Org Chem. 2022 Mar 22;18:331-336. doi: 10.3762/bjoc.18.37. eCollection 2022.
A facile one-pot synthesis of 5-unsubstituted dihydropyrimidinones from β,γ-unsaturated ketoesters in low melting ʟ-(+)-tartaric acid-,-dimethylurea mixtures is reported. This solvent-free method is very general and provides easy access to 5-unsubstituted dihydropyrimidinone-4-carboxylate derivatives in good yields.
报道了一种在低熔点L-(+)-酒石酸-N,N-二甲基脲混合物中由β,γ-不饱和酮酯一锅法简便合成5-未取代二氢嘧啶酮的方法。这种无溶剂方法非常通用，能以良好的产率轻松制得5-未取代二氢嘧啶酮-4-羧酸酯衍生物。
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