Measurement of beta-2-microglobulin in human cerebrospinal fluid by ELISA technique.

This study introduces an enzyme-linked immunosorbent assay for measurement of beta-2-microglobulin in human cerebrospinal fluid. The concentration of beta-2-microglobulin in cerebrospinal fluid correlated with the age (p less than 0.001) of a control group of 40 subjects, probably reflecting age-related processes in the central nervous system. The reference interval of beta-2-microglobulin was considered to be 0.62-3.28 mg/1. Results obtained with various CNS disorders demonstrated that estimation of beta-2-microglobulin in cerebrospinal fluid add diagnostic information. The concentration of beta-2-microglobulin may increase without simultaneous aberrations in the content of protein, glucose and white blood cells.