Departments of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Per Dubbsgatan 14, fl. 3, 413 45, Gothenburg, Sweden.
Department of Occupational Therapy and Physiotherapy, Sahlgrenska University Hospital, Gothenburg, Sweden.
Sci Rep. 2022 Apr 6;12(1):5779. doi: 10.1038/s41598-022-09520-2.
The objective was to investigate if pre-stroke physical activity is associated with intact cognition early after stroke. The study design was a cross-sectional, register-based study. The study sample included 1111 adults with first stroke (mild or moderate severity) admitted to three Swedish stroke units. The main outcome was cognition. The associations of pre-stroke physical activity, age, sex, smoking, diabetes, atrial fibrillation, previous TIA, statin treatment, hypertension treatment, reperfusion therapies, stroke severity, and education on the outcome cognition were analyzed using binary logistic regression. Physical activity was assessed within 48 h of admittance, and cognition was screened during stroke unit care. The results were: mean age 70 years, 40% women, 61% pre-stroke physically active, and 53% with post-stroke cognitive impairment. Patients with pre-stroke light or moderate physical activity have higher odds for intact cognition compared to inactive: odds ratio (95% confidence interval) 1.32 (0.97-1.80) and 2.04 (1.18-3.53), respectively. In addition to pre-stroke physical activity, people with younger age, a higher level of education, less severe stroke (more mild than moderate), being non-diabetic, and non-smoking have higher odds for intact cognition. In conclusion physical activity before stroke is associated with intact cognition in patients with mild and moderate stroke.
目的在于探究卒中前体力活动与卒中后早期认知功能是否完好之间的相关性。本研究设计为横断面、基于注册的研究。研究样本包括了 1111 名首次发生卒中（轻度或中度严重程度）的成年人，他们均被收治于瑞典的 3 所卒中单元。主要结局为认知功能。采用二项逻辑回归分析了卒中前体力活动、年龄、性别、吸烟、糖尿病、心房颤动、既往 TIA、他汀类药物治疗、高血压治疗、再灌注治疗、卒中严重程度和教育程度与认知结局的相关性。卒中前体力活动评估于入院后 48 小时内进行，认知功能筛查则在卒中单元治疗期间进行。结果显示：患者平均年龄为 70 岁，40%为女性，61%为卒中前体力活动活跃者，53%存在卒中后认知障碍。与不活跃者相比，卒中前轻体力活动或中体力活动者认知功能完好的可能性更高：优势比（95%置信区间）分别为 1.32（0.97-1.80）和 2.04（1.18-3.53）。除了卒中前体力活动之外，年龄较小、教育程度较高、卒中严重程度较低（更多为轻度而非中度）、无糖尿病和不吸烟的患者认知功能完好的可能性更高。总之，卒中前体力活动与轻度和中度卒中患者的认知功能完好相关。
