Fluvoxamine and long COVID-19; a new role for sigma-1 receptor (S1R) agonists.
作者信息
Khani Elnaz, Entezari-Maleki Taher
机构信息
Department of Clinical Pharmacy, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
出版信息
Mol Psychiatry. 2022 Sep;27(9):3562. doi: 10.1038/s41380-022-01545-3. Epub 2022 Apr 6.
Abstract
摘要
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Science. 2022 Jan 21;375(6578):296-301. doi: 10.1126/science.abj8222. Epub 2022 Jan 13.
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Mechanisms of action of fluvoxamine for COVID-19: a historical review.氟伏沙明治疗 COVID-19 的作用机制：历史回顾。
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Incidence, co-occurrence, and evolution of long-COVID features: A 6-month retrospective cohort study of 273,618 survivors of COVID-19.COVID-19 后 273618 例幸存者的 6 个月回顾性队列研究：长新冠症状的发生率、共病和演变。
PLoS Med. 2021 Sep 28;18(9):e1003773. doi: 10.1371/journal.pmed.1003773. eCollection 2021 Sep.
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Investigation of Long COVID Prevalence and Its Relationship to Epstein-Barr Virus Reactivation.“长新冠”患病率及其与爱泼斯坦-巴尔病毒再激活关系的调查
Pathogens. 2021 Jun 17;10(6):763. doi: 10.3390/pathogens10060763.
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Modulation of the sigma-1 receptor-IRE1 pathway is beneficial in preclinical models of inflammation and sepsis.调节 sigma-1 受体-IRE1 通路对炎症和脓毒症的临床前模型有益。
Sci Transl Med. 2019 Feb 6;11(478). doi: 10.1126/scitranslmed.aau5266.
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In vivo intratumoral Epstein-Barr virus replication is associated with XBP1 activation and early-onset post-transplant lymphoproliferative disorders with prognostic implications.体内肿瘤内爱泼斯坦-巴尔病毒复制与XBP1激活以及具有预后意义的移植后早期淋巴增殖性疾病相关。
Mod Pathol. 2014 Dec;27(12):1599-611. doi: 10.1038/modpathol.2014.68. Epub 2014 Apr 25.
7
Endoplasmic reticulum stress triggers XBP-1-mediated up-regulation of an EBV oncoprotein in nasopharyngeal carcinoma.内质网应激触发鼻咽癌中EBV一种癌蛋白的XBP-1介导的上调。
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