Department of Cardiology, Jilin FAW General Hospital, Changchun 130021, China.
Department of Neurology, Jilin FAW General Hospital, Changchun 130021, China.
J Healthc Eng. 2022 Mar 27;2022:1635446. doi: 10.1155/2022/1635446. eCollection 2022.
Coronary heart disease is a common disease threatening human health. In recent years, the incidence of coronary heart disease in China has only increased. It is the most common type of organ disease caused by coronary atherosclerosis, which is observed in the aorta, carotid artery, and femoral artery. The main clinical treatments for coronary heart disease include coronary artery bypass grafting and drug treatment. To investigate the relationship of serum adipocytokine C1q/tumor necrosis factor-related protein 9 (CTRP9), amyloid A (SAA), and plasma homocysteine (Hcy) with coronary artery plaque characteristics in patients with coronary heart disease. Overall, 143 patients with coronary heart disease admitted to our hospital are selected as research participants. The proportion of plaque necrosis core volume is higher in group A than in group B, and the differences are statistically significant ( < 0.05). In group A, necrotic core volume percentage is negatively correlated with CTRP9 levels and positively correlated with SAA and Hcy levels ( < 0.05). Logistic regression analysis revealed that increased systolic blood pressure, increased number of coronary artery lesions, decreased CTRP9 levels, and increased Hcy levels are independent risk factors for thin fibrous cap atherosclerosis in patients with coronary heart disease ( < 0.05). Decreased CTRP9 levels and increased Hcy levels are independent risk factors for coronary heart disease patients with thin fibrous cap atherosclerosis.
冠心病是一种威胁人类健康的常见疾病。近年来，我国冠心病的发病率只增不减。它是由冠状动脉粥样硬化引起的最常见的器官疾病类型，在主动脉、颈动脉和股动脉中均可观察到。冠心病的主要临床治疗方法包括冠状动脉旁路移植术和药物治疗。探讨血清脂肪细胞因子 C1q/肿瘤坏死因子相关蛋白 9（CTRP9）、淀粉样 A（SAA）和血浆同型半胱氨酸（Hcy）与冠心病患者冠状动脉斑块特征的关系。选取我院收治的冠心病患者 143 例作为研究对象。A 组斑块坏死核心体积比例高于 B 组，差异有统计学意义（ < 0.05）。A 组中，坏死核心体积百分比与 CTRP9 水平呈负相关，与 SAA 和 Hcy 水平呈正相关（ < 0.05）。Logistic 回归分析显示，收缩压升高、冠状动脉病变数量增加、CTRP9 水平降低和 Hcy 水平升高是冠心病患者薄帽纤维粥样硬化的独立危险因素（ < 0.05）。CTRP9 水平降低和 Hcy 水平升高是冠心病患者薄帽纤维粥样硬化的独立危险因素。
