Yang Weiming, Shen Li, Wang Anken, Li Meiyan, Yang Chenhao
Department of Ophthalmology, Children's Hospital of Fudan University, Shanghai, China.
Department of Ophthalmology and Optometry, Eye and ENT Hospital, Fudan University, Shanghai, China NHC Key Laboratory of Myopia (Fudan University), Shanghai Research Center of Ophthalmology and Optometry.
J Ophthalmol. 2022 Mar 28;2022:9954634. doi: 10.1155/2022/9954634. eCollection 2022.
To investigate the microbial profile of congenital nasolacrimal duct obstruction (CNLDO) in Chinese children.
We retrospectively reviewed the medical records of 330 consecutive children (330 eyes) who were diagnosed with tear duct infections secondary to CNLDO and were admitted to the Children's Hospital of Fudan University from January 2013 to January 2020. Bacterial cultures were grown from tear duct samples of each patient. Samples from conjunctival secretions were cultivated on blood or chocolate agar. Clinically significant bacterial growth was reported.
Of the 330 eyes considered, 62.7% (207/330) were associated with positive bacterial cultures. A total of 223 isolates were detected from 207 culture-positive eyes. Among the 223 isolates, 52.0% (116/223) were Gram-positive bacteria and 47.1% (105/223) were Gram-negative bacteria. The most prevalent Gram-positive bacteria were (67 isolates, 30%), followed by (36 isolates, 16.1%) and (5 isolates, 2.2%). The most prevalent Gram-negative bacteria were (nonpathogenic) (25 isolates, 11.2%), followed by (16 isolates, 7.2%) and (16 eyes, 7.2%). Antibiotic susceptibility test results suggested that both Gram-positive and Gram-negative bacteria were highly sensitive to most of the tested antibiotics.
and are the most prevalent bacteria in tear duct infections secondary to CNLDO. Broad-spectrum antibacterial eye drops are suggested as empirical antibiotic treatments.
研究中国儿童先天性鼻泪管阻塞（CNLDO）的微生物谱。
我们回顾性分析了2013年1月至2020年1月在复旦大学附属儿科医院收治的330例连续诊断为继发于CNLDO的泪道感染患儿（330只眼）的病历。对每位患者的泪道样本进行细菌培养。结膜分泌物样本在血琼脂或巧克力琼脂上培养。报告具有临床意义的细菌生长情况。
在330只眼中，62.7%（207/330）的眼细菌培养呈阳性。从207只培养阳性的眼中共检测到223株分离菌。在223株分离菌中，52.0%（116/223）为革兰氏阳性菌，47.1%（105/223）为革兰氏阴性菌。最常见的革兰氏阳性菌是[具体菌名1]（67株，30%），其次是[具体菌名2]（36株，16.1%）和[具体菌名3]（5株，2.2%）。最常见的革兰氏阴性菌是[具体菌名4]（非致病性）（25株，11.2%），其次是[具体菌名5]（16株，7.2%）和[具体菌名6]（16株，7.2%）。抗生素敏感性试验结果表明，革兰氏阳性菌和革兰氏阴性菌对大多数测试抗生素均高度敏感。
[具体菌名1]和[具体菌名4]是继发于CNLDO的泪道感染中最常见的细菌。建议使用广谱抗菌眼药水作为经验性抗生素治疗。
