Chen Kuang-Qi, Wei Bang-Hong, Hao Shuang-Li, Yang Wan-Xi
Department of Ophthalmology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
The Sperm Laboratory, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
Histol Histopathol. 2022 Jul;37(7):621-636. doi: 10.14670/HH-18-457. Epub 2022 Apr 7.
The PI3K/AKT signaling pathway is one of the most crucial regulatory mechanisms in animal cells, which can mainly regulate proliferation, survival and anti-apoptosis in cell lines. In the seminiferous epithelium, most studies were concentrated on the role of PI3K/AKT signaling in immature Sertoli cells (SCs) and spermatogonia stem cells (SSCs). PI3K/AKT signaling can facilitate the proliferation and anti-apoptosis of immature Sertoli cells and spermatogenic cells. Besides, in mature Sertoli cells, this pathway can disintegrate the structure of the blood-testis barrier (BTB) via regulatory protein synthesis and the cytoskeleton of Sertoli cells. All of these effects can directly and indirectly maintain and promote spermatogenesis in male testis.
PI3K/AKT信号通路是动物细胞中最关键的调节机制之一，主要可调节细胞系的增殖、存活和抗凋亡。在生精上皮中，大多数研究集中于PI3K/AKT信号在未成熟支持细胞（SCs）和精原干细胞（SSCs）中的作用。PI3K/AKT信号可促进未成熟支持细胞和生精细胞的增殖及抗凋亡。此外，在成熟支持细胞中，该通路可通过调节支持细胞的蛋白质合成和细胞骨架来破坏血睾屏障（BTB）的结构。所有这些作用均可直接或间接维持和促进雄性睾丸中的精子发生。
