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男性生殖健康-精子捐赠者人群研究。

Male Reproductive Health - study of a sperm donor population.

机构信息

USF Serpa Pinto, ACeS Grande Porto V - Porto Ocidental, Porto, Portugal.

Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal.

出版信息

JBRA Assist Reprod. 2022 Apr 17;26(2):247-254. doi: 10.5935/1518-0557.20210064.

DOI:10.5935/1518-0557.20210064
PMID:35389042
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9118971/
Abstract

OBJECTIVE

Every individual has the right to a safe and satisfactory sex and reproductive life. Therefore, several countries have made efforts to make Reproductive Health resources available to their populations. However, few results have been published regarding the policies implemented in Portugal. This study looked into the reproductive health status of the Portuguese male population.

METHODS

Sperm donor candidates from the Portuguese Public Gamete Bank registered between 2011 and 2018 were included in the study. Spermogram findings were evaluated with respect to sociodemographic and risk factors.

RESULTS

This is the first study performed in this population. We found that sperm quality has decreased throughout the last nine years, and that spermatozoa progressive motility is inversely correlated with the body mass index. An association between drug use and decreased sperm pH was also found.

CONCLUSIONS

Changes in sperm quality have important consequences in male fertility. Most of the identified causes of decreased sperm quality are modifiable factors and should therefore be addressed since an early age.

摘要

目的

每个人都有权享有安全和满意的性生活和生殖生活。因此,一些国家已经努力为其民众提供生殖健康资源。然而,关于葡萄牙实施的政策,发表的结果却很少。本研究调查了葡萄牙男性人口的生殖健康状况。

方法

本研究纳入了 2011 年至 2018 年期间在葡萄牙公共配子库登记的精子捐献者候选人。根据社会人口统计学和风险因素评估精液分析结果。

结果

这是在该人群中进行的第一项研究。我们发现,过去九年来精子质量下降,精子运动能力与体重指数呈负相关。还发现吸毒与精子 pH 值降低之间存在关联。

结论

精子质量的变化对男性生育能力有重要影响。大多数已确定的精子质量下降的原因是可改变的因素,因此应尽早解决。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1bf/9118971/d43aaf4274be/jbra-26-02-0247-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1bf/9118971/68a5de612928/jbra-26-02-0247-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1bf/9118971/d43aaf4274be/jbra-26-02-0247-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1bf/9118971/68a5de612928/jbra-26-02-0247-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1bf/9118971/d43aaf4274be/jbra-26-02-0247-g02.jpg

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本文引用的文献

1
The effects of age on sperm quality: an evaluation of 1,500 semen samples.年龄对精子质量的影响:对1500份精液样本的评估。
JBRA Assist Reprod. 2014 Jun 27;18(2):34-41. doi: 10.5935/1518-0557.20140002.
2
Payment to gamete donors: equality, gender equity, or solidarity?配子捐赠者的报酬:平等、性别公平还是团结?
J Assist Reprod Genet. 2020 Jan;37(1):133-140. doi: 10.1007/s10815-019-01625-4. Epub 2019 Nov 17.
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Male partners of subfertile couples in which the spouse is obese display adverse weight and lifestyle associated with reduced sperm quality.
晚期糖基化终产物膜结合受体(RAGE)是低质量精子的一种稳定生物标志物。
Hum Reprod Open. 2024 Nov 7;2024(4):hoae064. doi: 10.1093/hropen/hoae064. eCollection 2024.
不育夫妇中,如果配偶肥胖,那么男方伴侣的体重和生活方式往往不佳,这与精子质量下降有关。
Obes Res Clin Pract. 2019 May-Jun;13(3):226-232. doi: 10.1016/j.orcp.2019.03.001. Epub 2019 Mar 30.
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Smoking and infertility: a committee opinion.吸烟与不孕:委员会观点。
Fertil Steril. 2018 Sep;110(4):611-618. doi: 10.1016/j.fertnstert.2018.06.016.
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Lifestyle causes of male infertility.男性不育的生活方式成因。
Arab J Urol. 2018 Feb 13;16(1):10-20. doi: 10.1016/j.aju.2017.12.004. eCollection 2018 Mar.
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Fertility and infertility: Definition and epidemiology.生育与不孕:定义及流行病学
Clin Biochem. 2018 Dec;62:2-10. doi: 10.1016/j.clinbiochem.2018.03.012. Epub 2018 Mar 16.
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Influence of increasing body mass index on semen and reproductive hormonal parameters in a multi-institutional cohort of subfertile men.体重指数升高对不育男性多机构队列精液和生殖激素参数的影响。
Fertil Steril. 2016 Oct;106(5):1070-1075. doi: 10.1016/j.fertnstert.2016.06.041. Epub 2016 Jul 25.
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Cigarette Smoking and Semen Quality: A New Meta-analysis Examining the Effect of the 2010 World Health Organization Laboratory Methods for the Examination of Human Semen.吸烟与精液质量:一项新的荟萃分析,检验 2010 年世界卫生组织人类精液检查实验室方法的影响
Eur Urol. 2016 Oct;70(4):635-645. doi: 10.1016/j.eururo.2016.04.010. Epub 2016 Apr 21.
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Maternal Smoke Exposure Impairs the Long-Term Fertility of Female Offspring in a Murine Model.母体暴露于香烟烟雾会损害小鼠模型中雌性后代的长期生育能力。
Biol Reprod. 2016 Feb;94(2):39. doi: 10.1095/biolreprod.115.135848. Epub 2016 Jan 13.
10
Paternal obesity negatively affects male fertility and assisted reproduction outcomes: a systematic review and meta-analysis.父亲肥胖对男性生育能力和辅助生殖结果产生负面影响:一项系统综述和荟萃分析。
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