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运动训练对自发性高血压大鼠骨骼肌过氧化物酶体增殖物激活受体β/δ表达的影响。

Effects of Exercise Training on PPARβ/δ Expression in Skeletal Muscle of Rats with Spontaneous Hypertension.

机构信息

Department of Rehabilitation Therapy, School of Health, Fujian Medical University, Fuzhou, CHINA.

出版信息

Med Sci Sports Exerc. 2022 Aug 1;54(8):1309-1316. doi: 10.1249/MSS.0000000000002925. Epub 2022 Apr 2.

DOI:10.1249/MSS.0000000000002925
PMID:35389955
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9301982/
Abstract

PURPOSE

This study aimed to identify the relationship and mechanism between skeletal muscle peroxisome proliferator-activated receptor β/δ (PPARβ/δ) and spontaneous hypertension.

METHODS

Rats were divided into four groups ( n = 10): spontaneous hypertensive rats exercise group (SHR-E), spontaneous hypertensive rats sedentary group (SHR-S), Wistar-Kyoto control rats exercise group (WKY-E), and Wistar-Kyoto control rats sedentary group (WKY-S). Although the sedentary groups were placed on the treadmill without moving during the training sessions, the exercise groups were forced to run on a treadmill for 8 wk, 1 h·d -1 , 5 d·wk -1 . After training, the density and area of gastrocnemius microvessels were observed. PPARβ/δ, vascular endothelial growth factor A (VEGFA), superoxide dismutase 2 (SOD-2), and nitric oxide synthase in gastrocnemius were measured by real-time quantitative polymerase chain reaction (RT-qPCR) and Western blot.

RESULTS

Except the sixth week of age, the systolic blood pressure of SHR-S was significantly higher than that of WKY-S at all time periods. Exercise significantly reduced systolic blood pressure in SHR rats. Compared with the SHR-S group, the WKY-S group had significantly higher PPARβ/δ protein level and density of skeletal muscle microvessels. Eight weeks of exercise increased the PPARβ/δ, SOD-2, VEGFA, and microvessel density and area in the skeletal muscle of SHR.

CONCLUSIONS

Exercise training promoted PPARβ/δ mRNA and protein-level expression of PPARβ/δ, SOD-2 and VEGFA in skeletal muscle, thus increasing the density and area of skeletal muscle blood vessels. These regulations contribute to the reduction of peripheral vascular resistance. This may be a potential mechanism of exercise to reduce blood pressure.

摘要

目的

本研究旨在探讨骨骼肌过氧化物酶体增殖物激活受体β/δ（PPARβ/δ）与自发性高血压之间的关系和机制。

方法

将大鼠分为四组（n=10）：自发性高血压大鼠运动组（SHR-E）、自发性高血压大鼠安静组（SHR-S）、Wistar 京都对照大鼠运动组（WKY-E）和 Wistar 京都对照大鼠安静组（WKY-S）。虽然安静组在训练期间没有在跑步机上移动，但运动组被迫在跑步机上运动 8 周，每天 1 小时，每周 5 天。训练后，观察比目鱼肌微血管的密度和面积。通过实时定量聚合酶链反应（RT-qPCR）和 Western blot 测定比目鱼肌中 PPARβ/δ、血管内皮生长因子 A（VEGFA）、超氧化物歧化酶 2（SOD-2）和一氧化氮合酶的含量。

结果

除了 6 周龄外，SHR-S 的收缩压在所有时间点均明显高于 WKY-S。运动显著降低了 SHR 大鼠的收缩压。与 SHR-S 组相比，WKY-S 组的骨骼肌微血管 PPARβ/δ 蛋白水平和密度明显更高。8 周的运动增加了 SHR 骨骼肌中 PPARβ/δ、SOD-2、VEGFA 和微血管密度及面积。

结论

运动训练促进了骨骼肌中 PPARβ/δ 的 mRNA 和蛋白水平表达，增加了骨骼肌血管的密度和面积。这些调节有助于降低外周血管阻力。这可能是运动降低血压的潜在机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c76a/9301982/25eb8cc0badb/msse-54-1309-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c76a/9301982/d8c7fd890f1e/msse-54-1309-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c76a/9301982/5f41789bdfcc/msse-54-1309-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c76a/9301982/9201db37cfb0/msse-54-1309-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c76a/9301982/d0d5fd5c6e2a/msse-54-1309-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c76a/9301982/ab7353db4abc/msse-54-1309-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c76a/9301982/b0c793e4a7cf/msse-54-1309-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c76a/9301982/25eb8cc0badb/msse-54-1309-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c76a/9301982/d8c7fd890f1e/msse-54-1309-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c76a/9301982/5f41789bdfcc/msse-54-1309-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c76a/9301982/9201db37cfb0/msse-54-1309-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c76a/9301982/d0d5fd5c6e2a/msse-54-1309-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c76a/9301982/ab7353db4abc/msse-54-1309-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c76a/9301982/b0c793e4a7cf/msse-54-1309-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c76a/9301982/25eb8cc0badb/msse-54-1309-g007.jpg

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