Tectorigenin 通过抗炎和调节肠道微生物群改善高脂饮食诱导的非酒精性脂肪肝病。
Tectorigenin ameliorated high-fat diet-induced nonalcoholic fatty liver disease through anti-inflammation and modulating gut microbiota in mice.
机构信息
School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, PR China; National Grain Industry (Urban Grain and Oil Security) Technology Innovation Center, Shanghai, PR China.
School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, PR China; National Grain Industry (Urban Grain and Oil Security) Technology Innovation Center, Shanghai, PR China.
出版信息
Food Chem Toxicol. 2022 Jun;164:112948. doi: 10.1016/j.fct.2022.112948. Epub 2022 Apr 4.
Nonalcoholic fatty liver disease (NAFLD) is a complex pathogenesis of liver disease combined with liver inflammation and gut microbiota dysbiosis. Tectorigenin (Tg) is derived from many plants with excellent anti-inflammation activity. However, the beneficial effect of Tg on NAFLD associated with gut microbiota remained unclear. This study aimed to investigate the underlying beneficial effect of Tg on NAFLD in high-fat diet (HFD)-fed mice. Results showed that Tg alleviated lipid profiles and liver steatosis, and reduced serum lipopolysaccharide (LPS) and total bile acid (TBA) levels. Besides, RT-qPCR and Western blot suggested that Tg alleviated hepatic lipid accumulation through inhibiting the lipogenesis and promoting the lipolysis, prevented gut-derived LPS-induced liver inflammatory via restoring intestinal barrier and restraining pro-inflammatory cytokines release, meanwhile, promoted the BA circulation via activating BA receptor and promoting BA synthesis. Moreover, Tg reverted the HFD-induced gut microbial dysbiosis by promoting the growth of beneficial Akkermansia, and inhibiting the proportions of harmful microbes, including Blautia, Lachnoclostridium, Lachnospiraceae_UCG-006, Roseburia, Romboutsia and Faecalibaculum, which were highly correlated with NAFLD-related parameters in serum and liver. Thus, Tg could attenuate NAFLD through mediating the liver-gut axis, and it could be used as a dietary supplement for NAFLD treatment via its anti-inflammatory and prebiotic effects.
非酒精性脂肪性肝病（NAFLD）是一种复杂的肝脏疾病发病机制，其与肝脏炎症和肠道微生物失调有关。葛根素（Tg）是从许多具有良好抗炎活性的植物中提取的。然而，Tg 对与肠道微生物相关的 NAFLD 的有益作用尚不清楚。本研究旨在探讨 Tg 对高脂饮食（HFD）喂养小鼠 NAFLD 的潜在有益作用。结果表明，Tg 缓解了血脂谱和肝脂肪变性，并降低了血清脂多糖（LPS）和总胆汁酸（TBA）水平。此外，RT-qPCR 和 Western blot 表明，Tg 通过抑制脂肪生成和促进脂肪分解来缓解肝脂肪堆积，通过恢复肠道屏障和抑制促炎细胞因子释放来防止肠道来源的 LPS 诱导的肝炎症，同时通过激活 BA 受体和促进 BA 合成来促进 BA 循环。此外，Tg 通过促进有益菌阿克曼氏菌的生长和抑制有害菌（包括布劳特氏菌、lachnoclostridium、lachnospiraceae_uCG-006、Roseburia、Romboutsia 和 Faecalibaculum）的比例，逆转了 HFD 诱导的肠道微生物失调，这些菌与血清和肝脏中的 NAFLD 相关参数高度相关。因此，Tg 可以通过调节肝肠轴来减轻 NAFLD，并且可以通过其抗炎和益生元作用被用作 NAFLD 治疗的膳食补充剂。
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