Jackson Kristina Harris, Harris William S
OmegaQuant Analytics, LLC, the Fatty Acid Research Institute; and Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, 57105 United States of America.
OmegaQuant Analytics, LLC, the Fatty Acid Research Institute; and Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, 57105 United States of America.
Prostaglandins Leukot Essent Fatty Acids. 2022 Apr;179:102417. doi: 10.1016/j.plefa.2022.102417. Epub 2022 Mar 23.
Recent trials in pregnant women on the effects of supplemental DHA on early preterm birth (ePTB) risk have shown that there is a maternal blood docosahexaenoic acid (DHA) level below which risk for ePTB was increased and supplemental DHA was effective at reducing risk. However, DHA levels were expressed in different terms across these trials making cross study comparisons impossible. The purposes of this study were 1) to report interlaboratory conversion factors from study-specific metrics to a common metric, red blood cell (RBC) DHA measured by OmegaQuant Analytics (OQA), and 2) to translate reported pre- and post-treatment DHA levels from these trials into a RBC DHA for comparison. Data from five published and one unpublished study are included. Across these studies, the effects on RBC DHA levels after supplementation with 0, 200, 600, 800 and 1000 mg of DHA were (as a% change from baseline): 0 mg, no change; 200 mg, 15-20% increase; 600 mg, 55-60% increase; 800 mg, 13-65% increase; and 1000 mg, 51% increase. Standardization of fatty acid analysis and reporting and a target omega-3 or DHA level for identifying those for which higher dose DHA supplementation is indicated to prevent ePTB are needed for clinical use.
近期针对孕妇补充二十二碳六烯酸（DHA）对早期早产（ePTB）风险影响的试验表明，存在一个母体血液二十二碳六烯酸（DHA）水平，低于该水平时ePTB风险会增加，而补充DHA可有效降低风险。然而，这些试验中DHA水平的表述方式各不相同，使得跨研究比较无法进行。本研究的目的是：1）报告从特定研究指标到通用指标（由OmegaQuant Analytics（OQA）测量的红细胞（RBC）DHA）的实验室间转换因子；2）将这些试验中报告的治疗前和治疗后DHA水平转换为RBC DHA进行比较。纳入了五项已发表研究和一项未发表研究的数据。在这些研究中，补充0、200、600、800和1000毫克DHA后对RBC DHA水平的影响（以相对于基线的百分比变化表示）为：0毫克，无变化；200毫克，增加15 - 20%；600毫克，增加55 - 60%；800毫克，增加13 - 65%；1000毫克，增加51%。临床应用需要脂肪酸分析和报告的标准化以及用于确定哪些人需要更高剂量DHA补充以预防ePTB的目标ω-3或DHA水平。
