Offenloch K, Zahner G, Dietlein G, Franz I
Arzneimittelforschung. 1986 Sep;36(9):1401-6.
The efficacy and tolerability of Scopoderm TTS (SCOTTS), a transdermal system containing scopolamine, were compared with those of the oral antiemetic dimenhydrinate (double-dummy technique) in a controlled, double-blind, within-patient study including 20 test persons with proven motion sickness. During a 1-h test flight, SCOTTS proved to be as effective as dimenhydrinate. The efficacy and tolerability of both SCOTTS and dimenhydrinate were assessed as to be equally good. Due to its galenic properties, SCOTTS is effective over a 72-h period and therefore is useful in the prevention of motion sickness during long-distance flights, where it is superior to dimenhydrinate.
在一项纳入20名经证实有晕动病的试验对象的对照、双盲、自身对照研究中，将含有东莨菪碱的透皮系统Scopoderm TTS（SCOTTS）与口服止吐药茶苯海明（采用双模拟技术）的疗效和耐受性进行了比较。在一次1小时的试飞期间，SCOTTS被证明与茶苯海明一样有效。SCOTTS和茶苯海明的疗效和耐受性均被评估为同样良好。由于其药剂学特性，SCOTTS在72小时内均有效，因此在预防长途飞行期间的晕动病方面很有用，在这方面它优于茶苯海明。
