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高剂量化疗后自体骨髓移植治疗成年急性髓系白血病患者

Autologous bone marrow transplantation following high dose chemotherapy for the treatment of adult patients with acute myeloid leukaemia.

作者信息

Goldstone A H, Anderson C C, Linch D C, Franklin I M, Boughton B J, Cawley J C, Richards J D

出版信息

Br J Haematol. 1986 Nov;64(3):529-37. doi: 10.1111/j.1365-2141.1986.tb02209.x.

DOI:10.1111/j.1365-2141.1986.tb02209.x
PMID:3539175
Abstract

24 adult patients with acute myeloid leukaemia (AML) were treated with intensive chemotherapy followed by autologous marrow rescue. The procedure was repeated twice in eight patients. 11 of 16 patients treated in first remission continue in first unmaintained remission (9-54 months, median 17 months). Eight patients treated at relapse or second remission have relapsed again and died within 14 months of their first autologous bone marrow transplant (ABMT). This form of intensification therapy would appear valuable for adult AML patients in first remission.

摘要

24例成年急性髓系白血病(AML)患者接受了强化化疗,随后进行自体骨髓挽救。8例患者重复了该过程两次。首次缓解期接受治疗的16例患者中有11例持续处于首次未维持缓解状态(9 - 54个月,中位时间17个月)。8例在复发期或第二次缓解期接受治疗的患者再次复发,并在首次自体骨髓移植(ABMT)后的14个月内死亡。这种强化治疗形式对首次缓解期的成年AML患者似乎有价值。

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引用本文的文献

1
Bone marrow transplantation. Part II--autologous.骨髓移植。第二部分——自体移植。
West J Med. 1990 Jan;152(1):46-51.