环孢素A：对兔子进行局部和全身给药后的组织水平
Cyclosporin A: tissue levels following topical and systemic administration to rabbits.
作者信息
Bell T A, Hunnisett A G
出版信息
Br J Ophthalmol. 1986 Nov;70(11):852-5. doi: 10.1136/bjo.70.11.852.
Plasma and aqueous levels of cyclosporin A (CsA) were determined following topical administration of CsA 1% to healthy rabbit eyes and compared with levels obtained when administered to rabbit eyes which had received corneal grafts 7-10 days previously. In addition plasma levels were determined following intramuscular administration of 50 mg CsA and the results compared with those obtained following topical administration. Topical administration to healthy rabbit eyes five times a day for three days resulted in plasma levels of CsA which were similar to those obtained over three days following an intramuscular administration of 50 mg CsA. The plasma levels in both were significantly higher than those obtained following topical administration to rabbit eyes which had received corneal grafts 7-10 days previously. Aqueous levels of CsA were lower than plasma levels, and there was no significant difference between levels obtained when CsA was administered topically to healthy eyes, to eyes which had received corneal grafts, or to the fellow eye.
将1%的环孢素A（CsA）局部应用于健康兔眼后，测定其血浆和房水水平，并与应用于7 - 10天前接受角膜移植的兔眼时所获得的水平进行比较。此外，在肌肉注射50 mg CsA后测定血浆水平，并将结果与局部应用后所获得的结果进行比较。连续三天每天五次对健康兔眼进行局部应用，所产生的CsA血浆水平与肌肉注射50 mg CsA三天后所获得的水平相似。两者的血浆水平均显著高于7 - 10天前接受角膜移植的兔眼局部应用后所获得的水平。CsA的房水水平低于血浆水平，当CsA局部应用于健康眼、接受角膜移植的眼或对侧眼时，所获得的水平之间无显著差异。
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