Alghadyan A A, Peyman G A, Khoobehi B, Milner S, Liu K R
LSU Eye Center, Louisiana State University Medical Center School of Medicine, New Orleans.
Int Ophthalmol. 1988;12(2):109-12. doi: 10.1007/BF00137135.
The concentration of cyclosporine in the vitreous after intravitreal injection of 100 micrograms of either free or liposome-bound cyclosporine was studied in albino rabbits. We found that the half-life of free cyclosporine was about 6 hours and that of liposome-bound cyclosporine was about 3 days. The finding indicates that liposome-bound cyclosporine prolongs the availability of the drug.
