Agu G O, Rajkumar K, Murphy B D
Biol Reprod. 1986 Oct;35(3):508-15. doi: 10.1095/biolreprod35.3.508.
The role of dopaminergic agents in prolactin (Prl) release and the luteotrophic role of Prl and luteinizing hormone (LH) were investigated in pseudopregnant female ferrets. A single injection of the dopamine antagonist pimozide (0.63 mg/kg) resulted in a tenfold elevation of plasma Prl in anestrous females. Subcutaneous injection of pimozide on alternate days from Day 2 through Day 16 of pseudopregnancy elevated both Prl and progesterone levels. Daily treatment with the dopamine agonist 2 alpha-bromoergocryptine (bromocriptine, 4 mg/kg), from Day 2 through Day 16 of pseudopregnancy lowered levels of both plasma Prl and progesterone. Neither pimozide nor bromocriptine had a direct effect on progesterone secretion by luteal cells in vitro. Daily intraperitoneal administration of a monoclonal antibody against gonadotropin-releasing hormone from Day 2 through Day 10 of pseudopregnancy lowered both plasma LH and progesterone, but had no effect on plasma Prl concentrations. Daily administration of equine antisera against bovine LH or 100 IU of human chorionic gonadotrophin to pseudopregnant ferrets lowered progesterone levels. It is concluded that Prl release is influenced by dopaminergic compounds, and both Prl and LH are required for luteal maintenance in the ferret.
在假孕雌性雪貂中研究了多巴胺能药物在催乳素（Prl）释放中的作用以及Prl和促黄体生成素（LH）的促黄体作用。单次注射多巴胺拮抗剂匹莫齐特（0.63mg/kg）可使处于静止期的雌性雪貂血浆Prl升高10倍。在假孕第2天至第16天隔日皮下注射匹莫齐特可使Prl和孕酮水平均升高。在假孕第2天至第16天每天用多巴胺激动剂2α-溴麦角隐亭（溴隐亭，4mg/kg）治疗可降低血浆Prl和孕酮水平。匹莫齐特和溴隐亭在体外对黄体细胞分泌孕酮均无直接作用。在假孕第2天至第10天每天腹腔注射抗促性腺激素释放激素单克隆抗体可降低血浆LH和孕酮水平，但对血浆Prl浓度无影响。给假孕雪貂每天注射抗牛LH马抗血清或100IU人绒毛膜促性腺激素可降低孕酮水平。得出的结论是，Prl释放受多巴胺能化合物影响，并且Prl和LH都是雪貂维持黄体所必需的。
