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长链非编码RNA RP11-138J23.1通过与RNA结合蛋白HuR相互作用促进胃癌进展。

LncRNA RP11-138J23.1 Contributes to Gastric Cancer Progression by Interacting With RNA-Binding Protein HuR.

作者信息

Xu Yongcan, Yu Xiang, Xu Jing, Lu Jun, Jiang Hao, Lou Neng, Lu Wei, Xu Jiewei, Ye Guochao, Dong Shunli, Nie Fengqi

机构信息

Department of General Surgery, Huzhou Central Hospital, Affiliated Central Hospital, Huzhou University, Huzhou, China.

Department of General Surgery, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yanta, China.

出版信息

Front Oncol. 2022 Mar 22;12:848406. doi: 10.3389/fonc.2022.848406. eCollection 2022.

DOI:10.3389/fonc.2022.848406
PMID:35392234
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8980803/
Abstract

In spite of improvements in diagnostics and treatment of gastric cancer (GC), it remains the most common malignancy of human digestive system. It is now widely appreciated that long noncoding RNAs (lncRNAs) exert extensive regulatory effects on a spectrum of fundamental biological processes through diverse mechanisms. In this study, we explored the expression level and functional role of lncRNA RP11-138J23.1 in GC. Through bioinformatics analyses and hybridization (ISH), we identified that RP11-138J23.1 was upregulated in GC tissue. Further study showed that RP11-138J23.1 knockdown significantly inhibited cell proliferation and metastatic ability. Whereas, RP11-138J23.1 overexpression could promote tumor cell growth and metastasis . Additionally, loss-of-function assays were used to confirm the role of RP11-138J23.1 . Mechanistically, RP11-138J23.1 exerted its oncogenic functions by binding to HuR protein and increasing stability of VAV3 mRNA. Overall, our study highlights the essential role of RP11-138J23.1 in GC, suggesting that RP11-138J23.1 might be a potent therapeutic target for patients with GC.

摘要

尽管胃癌（GC）的诊断和治疗有所改善，但它仍然是人类消化系统最常见的恶性肿瘤。现在人们普遍认识到，长链非编码RNA（lncRNAs）通过多种机制对一系列基本生物学过程发挥广泛的调节作用。在本研究中，我们探讨了lncRNA RP11-138J23.1在胃癌中的表达水平和功能作用。通过生物信息学分析和原位杂交（ISH），我们发现RP11-138J23.1在胃癌组织中上调。进一步研究表明，敲低RP11-138J23.1可显著抑制细胞增殖和转移能力。而RP11-138J23.1过表达可促进肿瘤细胞生长和转移。此外，通过功能丧失实验来证实RP11-138J23.1的作用。机制上，RP11-138J23.1通过与HuR蛋白结合并增加VAV3 mRNA的稳定性发挥其致癌功能。总体而言，我们的研究突出了RP11-138J23.1在胃癌中的重要作用，表明RP11-138J23.1可能是胃癌患者的一个有效的治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/384f/8980803/021d4be5ccd8/fonc-12-848406-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/384f/8980803/09ef6440895e/fonc-12-848406-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/384f/8980803/7008dc6b9f80/fonc-12-848406-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/384f/8980803/88f4c1675602/fonc-12-848406-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/384f/8980803/d62688408a06/fonc-12-848406-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/384f/8980803/28cb4c9d9e17/fonc-12-848406-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/384f/8980803/78dcfc730373/fonc-12-848406-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/384f/8980803/021d4be5ccd8/fonc-12-848406-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/384f/8980803/09ef6440895e/fonc-12-848406-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/384f/8980803/7008dc6b9f80/fonc-12-848406-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/384f/8980803/88f4c1675602/fonc-12-848406-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/384f/8980803/d62688408a06/fonc-12-848406-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/384f/8980803/28cb4c9d9e17/fonc-12-848406-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/384f/8980803/78dcfc730373/fonc-12-848406-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/384f/8980803/021d4be5ccd8/fonc-12-848406-g007.jpg

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