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血浆 Ninjurin-1 水平升高与心房颤动的心房重构和血栓栓塞风险相关。

Elevated plasma Ninjurin-1 levels in atrial fibrillation is associated with atrial remodeling and thromboembolic risk.

机构信息

Heart Center & Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, 8th Gongtinanlu Rd, Chaoyang District, Beijing, 100020, China.

出版信息

BMC Cardiovasc Disord. 2022 Apr 7;22(1):153. doi: 10.1186/s12872-022-02593-x.

DOI:10.1186/s12872-022-02593-x
PMID:35392805
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8991886/
Abstract

BACKGROUND

Nerve injury-induced protein 1 (Ninj1) is elevated in various inflammatory diseases. The soluble form of Ninj1 yield by matrix metalloproteinase cleavage is a secreted protein and inhibits cell adhesion and inflammation. However, the role of plasma Ninj1 in atrial fibrillation (AF) has not been reported. The present study aimed to investigate the correlation between plasma Ninj1 levels and AF.

METHODS

A total of 96 AF patients [age 66.00 (60.00, 72.00) years, male 56 (58.33%)] and 51 controls without AF [age 65.00 (55.00, 68.00) years, male 21 (41.18%)] were enrolled in this study. Plasma Ninj1 concentrations were detected using enzyme-linked immunosorbent assay. Also, the clinical characteristics, left atrial volume index (LAVI), CHA2DS2-VASc score, and HAS-BLED score were evaluated.

RESULTS

Plasma Ninj1 levels were significantly higher in patients with AF than in controls (P < 0.001). Plasma Ninj1 levels were positively correlated with LAVI (P = 0.019) and CHA2DS2-VASc score (P = 0.024). Logistic regression analysis confirmed that the Ninj1 plasma levels were associated with AF (P = 0.009). The receiver operating characteristic analysis showed that plasma Ninj1 had a predictive value for AF (P < 0.001).

CONCLUSIONS

Plasma Ninj1 levels were elevated in patients with AF, associated with left atrial enlargement and thromboembolic risk in AF.

摘要

背景

神经损伤诱导蛋白 1（Ninj1）在各种炎症性疾病中升高。基质金属蛋白酶切割产生的 Ninj1 的可溶性形式是一种分泌蛋白，可抑制细胞黏附和炎症。然而，血浆 Ninj1 在心房颤动（AF）中的作用尚未报道。本研究旨在探讨血浆 Ninj1 水平与 AF 的相关性。

方法

共纳入 96 例 AF 患者[年龄 66.00（60.00，72.00）岁，男性 56 例（58.33%）]和 51 例无 AF 对照者[年龄 65.00（55.00，68.00）岁，男性 21 例（41.18%）]。采用酶联免疫吸附试验检测血浆 Ninj1 浓度。同时评估临床特征、左心房容积指数（LAVI）、CHA2DS2-VASc 评分和 HAS-BLED 评分。

结果

AF 患者的血浆 Ninj1 水平明显高于对照组（P<0.001）。血浆 Ninj1 水平与 LAVI（P=0.019）和 CHA2DS2-VASc 评分（P=0.024）呈正相关。Logistic 回归分析证实 Ninj1 血浆水平与 AF 相关（P=0.009）。受试者工作特征曲线分析显示，血浆 Ninj1 对 AF 具有预测价值（P<0.001）。

结论

AF 患者的血浆 Ninj1 水平升高，与左心房扩大和 AF 中的血栓栓塞风险相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac87/8991886/23120440faef/12872_2022_2593_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac87/8991886/56387c40249a/12872_2022_2593_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac87/8991886/8994f7ddf5f1/12872_2022_2593_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac87/8991886/23120440faef/12872_2022_2593_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac87/8991886/56387c40249a/12872_2022_2593_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac87/8991886/8994f7ddf5f1/12872_2022_2593_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac87/8991886/23120440faef/12872_2022_2593_Fig3_HTML.jpg

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