Department of Endocrinology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Lucheng District, Wenzhou, Zhejiang Province, People's Republic of China.
BMC Surg. 2022 Apr 7;22(1):133. doi: 10.1186/s12893-022-01575-2.
Currently, the surgical outcomes of gallbladder cancer (GBC) are not always satisfactory. The geriatric nutritional risk index (GNRI) can effectively assess nutritional status. This study intends to investigate whether the preoperative GNRI can predict the prognosis of GBC.
202 consecutive GBC patients who underwent treatment from 2010 to 2017 were selected and analyzed retrospectively. By using the univariate and multivariate Cox regression analyses on overall survival (OS) and recurrence-free survival (RFS), the preoperative GNRI of GBC patients was evaluated.
Among the 202 patients, the GNRI of the 86 patients (42.6%) was less than 98. The patients with low preoperative GNRI had the median OS of 26 months, which was less than the median OS of 39 months among those patients who had higher preoperative GNRI (P < 0.001). Univariate analysis showed that low GNRI was related to short survival time (HR 3.656, 95% CI 2.308-5.790, P < 0.001). In addition, the results of multivariate analysis revealed that, the patients with low GNRI showed a lower OS (HR 2.207, 95% CI 1.131-4.308, P = 0.020) and RFS (HR 2.964, 95% CI 1.577-5.571, P = 0.001) than those patients with higher GNRI.
GNRI is an independent indicator of poor prognosis in GBC patients after GBC radical surgery.
目前，胆囊癌（GBC）的手术治疗效果并不总是令人满意。老年营养风险指数（GNRI）能有效评估营养状况。本研究旨在探讨术前 GNRI 是否能预测 GBC 的预后。
回顾性分析 2010 年至 2017 年间接受治疗的 202 例连续 GBC 患者。通过对总生存（OS）和无复发生存（RFS）的单因素和多因素 Cox 回归分析，评估 GBC 患者的术前 GNRI。
在 202 例患者中，86 例（42.6%）患者的 GNRI 小于 98。术前 GNRI 较低的患者中位 OS 为 26 个月，短于术前 GNRI 较高的患者中位 OS 39 个月（P<0.001）。单因素分析显示，低 GNRI 与生存时间短相关（HR 3.656，95%CI 2.308-5.790，P<0.001）。此外，多因素分析结果表明，低 GNRI 患者 OS（HR 2.207，95%CI 1.131-4.308，P=0.020）和 RFS（HR 2.964，95%CI 1.577-5.571，P=0.001）均较 GNRI 较高的患者差。
GNRI 是 GBC 根治术后 GBC 患者预后不良的独立指标。
