Cuzick J, Stewart H, Peto R, Fisher B, Kaae S, Johansen H, Lythgoe J P, Prescott R J
Cancer Treat Rep. 1987 Jan;71(1):7-14.
An overview of mortality in the mature randomized trials comparing radical mastectomy without radiotherapy against simple mastectomy with radiotherapy has been conducted. These trials mark a transitional period between radical mastectomy and simple mastectomy as the generally preferred surgical treatment and as such are not strictly trials assessing the value of postoperative adjuvant radiotherapy. All known mature trials have been included and these four trials have entered a total of 3236 patients, in whom 1678 deaths have been recorded. Overall, no significant difference in survival was seen, but there was a nonsignificant trend for patients given radiotherapy to do worse after 15 years of follow-up.
对比较不放疗的根治性乳房切除术与放疗的单纯乳房切除术的成熟随机试验中的死亡率进行了概述。这些试验标志着根治性乳房切除术和单纯乳房切除术之间的过渡时期，当时单纯乳房切除术是普遍首选的手术治疗方法，因此这些试验并非严格评估术后辅助放疗价值的试验。已纳入所有已知的成熟试验，这四项试验共纳入3236例患者，其中记录了1678例死亡病例。总体而言，未观察到生存率有显著差异，但在15年的随访后，接受放疗的患者有情况更差的非显著趋势。
