Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
IRCCS Mondino Foundation, Pavia, Italy.
J Clin Sleep Med. 2022 Sep 1;18(9):2313-2316. doi: 10.5664/jcsm.9988.
Kleine-Levin syndrome is a rare neurologic disorder of unknown etiopathogenesis, characterized by abrupt onset and remission of attacks of hypersomnia and cognitive dysfunctions. Psychiatric symptoms are frequently present, ranging from disinhibited sexual behavior and eating disorders to hallucinations, anxiety, mood alterations, and derealization. A vast range of attack-related dysautonomic signs and symptoms are reported but remain poorly described. We describe a patient with Kleine-Levin syndrome with sleep attacks dominated by marked dysautonomic features. We briefly review similar clinical cases and suggest that the hypothalamus may play a central role in the genesis of autonomic dysfunction in Kleine-Levin syndrome.
Fiamingo G, Esposto R, Dal Fabbro B, Terzaghi M. Kleine-Levin syndrome: report of a case with marked dysautonomic features. . 2022;18(9):2313-2316.
克莱恩-莱文综合征是一种罕见的神经系统疾病，病因不明，其特征为突发性和缓解性发作性嗜睡和认知功能障碍。常伴有精神症状，从性欲倒错和饮食障碍到幻觉、焦虑、情绪改变和现实解体。据报道，与发作相关的自主神经症状和体征范围广泛，但描述不佳。我们描述了一例以明显自主神经功能障碍为特征的克莱恩-莱文综合征睡眠发作患者。我们简要回顾了类似的临床病例，并提出下丘脑可能在克莱恩-莱文综合征自主神经功能障碍的发病机制中起核心作用。
Fiamingo G, Esposto R, Dal Fabbro B, Terzaghi M. Kleine-Levin syndrome: report of a case with marked dysautonomic features.. 2022;18(9):2313-2316.
