State Key Laboratory of Materials-Oriented Chemical Engineering, College of Food Science and Light Industry, Nanjing Tech University, Nanjing 211816, China.
School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China.
Biomater Sci. 2022 May 4;10(9):2417-2427. doi: 10.1039/d2bm00183g.
Adhesives for gastric hemorrhage are of great clinical significance. However, it remains a major challenge in clinics due to its poor stability under acidic environments and low adhesion to wet tissues. Herein, inspired by the high adhesiveness of the ascidian secretory protein, we designed a series of aciduric bionic hydrogel adhesives (PDTAs) based on poly(γ-glutamic acid) (γ-PGA) and tannic acid (TA). The formation of hydrogel adhesives was attributed to the abundant hydrogen bonds between amide groups of PGA-DA and polyphenol groups of TA. These hydrogel adhesives exhibited enhanced wet tissue adhesion (400%), higher stretchability (800% elongation), and aciduric stability (7 days) compared with commercial fibrin glue. Rodent wound models indicated that the hydrogel adhesives demonstrated significant healing promotion due to ameliorating collagen deposition and angiogenesis. These hydrogel adhesives show great potential in treating gastric hemorrhages and promoting wound healing.
用于胃出血的黏合剂具有重要的临床意义。然而，由于其在酸性环境下稳定性差，并且对湿组织的黏附力低，因此在临床上仍然是一个主要挑战。受藤壶分泌蛋白高黏附性的启发，我们基于聚（γ-谷氨酸）（γ-PGA）和鞣酸（TA）设计了一系列耐酸仿生水凝胶黏合剂（PDTAs）。水凝胶黏合剂的形成归因于 PGA-DA 的酰胺基团和 TA 的多酚基团之间丰富的氢键。与商业纤维蛋白胶相比，这些水凝胶黏合剂表现出增强的湿组织黏附性（400%）、更高的拉伸性（800%伸长率）和耐酸性稳定性（7 天）。啮齿动物伤口模型表明，由于改善了胶原沉积和血管生成，水凝胶黏合剂表现出显著的促进愈合作用。这些水凝胶黏合剂在治疗胃出血和促进伤口愈合方面具有巨大的潜力。
