Key Laboratory of Advance Technologies of Materials, Ministry of Education, College of Medicine, School of Materials Science and Engineering, Southwest Jiaotong University, 610031, Chengdu, China.
Chengdu University of Traditional Chinese Medicine, School of Intelligent Medicine, Chengdu, 611137, China.
Adv Healthc Mater. 2023 Nov;12(29):e2301560. doi: 10.1002/adhm.202301560. Epub 2023 Aug 13.
The application of most hydrogel bio-adhesives is greatly limited due to their high swelling, low underwater adhesion, and single function. Herein, a spatial multi-level physical-chemical and bio-inspired in-situ bonding strategy is proposed, to develop a multifunctional hydrogel bio-glue using polyglutamic acid (PGA), tyramine hydrochloride (TYR), and tannic acid (TA) as precursors and 4-(4,6-dimethoxytriazine-2-yl) -4-methylmorpholine hydrochloride(DMTMM) as condensation agent, which is used for tissue adhesion, hemostasis and repair. By introducing TYR and TA into the PGA chain, it is demonstrated that not only can the strong adhesion of bio-glue to the surface of various fresh tissues and wet materials be realized through the synergistic effect of spatial multi-level physical and chemical bonding, but also this glue can be endowed with the functions of anti-oxidation and hemostasis. The excellent performance of such bio-glue in the repair of the wound, liver, and cartilage is achieved, showing a great potential in clinical application for such bio-glue. This study will open up a brand-new avenue for the development of multifunctional hydrogel biological adhesive.
由于水凝胶生物粘合剂的高溶胀性、水下低粘附性和单一功能，其应用受到了极大的限制。在此，提出了一种空间多级物理化学和仿生原位键合策略，以多聚谷氨酸（PGA）、盐酸酪胺（TYR）和单宁酸（TA）为前体，4-（4,6-二甲氧基三嗪-2-基）-4-甲基吗啉盐酸盐（DMTMM）为缩合剂，开发出一种多功能水凝胶生物胶，用于组织黏合、止血和修复。通过将 TYR 和 TA 引入 PGA 链中，证明通过空间多级物理化学协同作用，不仅可以实现生物胶对各种新鲜组织和湿材料表面的强粘附，而且还可以赋予该胶抗氧化和止血功能。这种生物胶在伤口、肝脏和软骨修复方面的优异性能，显示出其在临床应用方面的巨大潜力。本研究将为多功能水凝胶生物粘合剂的开发开辟一条全新的途径。
