Rehbein Steffen, Hamel Dietmar, Yoon Stephen, Fankhauser Becky
Boehringer Ingelheim Vetmedica GmbH, Kathrinenhof Research Center, Walchenseestr. 8-12, 83101, Rohrdorf, Germany.
Boehringer Ingelheim Animal Health USA, Inc, 3239 Satellite Blvd, Duluth, GA, 30096-4640, USA.
Parasitol Res. 2022 Jun;121(6):1811-1815. doi: 10.1007/s00436-022-07515-6. Epub 2022 Apr 8.
The objective of this controlled study was to determine the anthelmintic efficacy of eprinomectin 5% w/v extended-release injection (Eprinomectin ERI; LONGRANGE®, Boehringer Ingelheim Animal Health) against primarily ovine-adapted gastrointestinal strongylid nematode (GIN) parasites in naturally infected young cattle. Eighteen calves which grazed on a sheep-dominated mixed sheep-cattle farm were randomly allocated into two equal groups (saline [control] or Eprinomectin ERI, administered each at 1 mL/50 kg body weight once subcutaneously), treated and euthanized 14 days thereafter for a differential GIN count. Ten species of strongylid nematodes were recovered from the control calves (ovine-adapted Haemonchus contortus, Teladorsagia circumcincta, Trichostrongylus colubriformis, Cooperia curticei, Nematodirus battus, Chabertia ovina; bovine-adapted Ostertagia ostertagi, Cooperia oncophora, Nematodirus helvetianus; 'generalist' Trichostrongylus axei). Adult GIN counts ranged from 1,540 to 5,244 for the control calves and from zero to 110 for the Eprinomectin ERI-treated calves. Accepting the International Cooperation on Harmonisation of Technical Requirements for Registration of Veterinary Medicinal Products anthelmintic guidelines criteria on adequacy of infections to be demonstrated in the control animals, this study showed that Ch. ovina, C. curticei, H. contortus, N. battus, T. axei, and T. colubriformis were reduced significantly (p < 0.0001) by ≥ 98.7% in the animals treated with Eprinomectin ERI. In conclusion, Eprinomectin ERI treatment was efficacious against a range of ovine-adapted nematode parasites in naturally infected young cattle.
这项对照研究的目的是确定5% w/v的爱泼菌素长效注射剂（爱泼菌素ERI；“朗瑞奇”，勃林格殷格翰动物保健公司）对自然感染的幼龄牛体内主要适应绵羊的胃肠道圆线虫（GIN）寄生虫的驱虫效果。在一个以绵羊为主的绵羊 - 牛混合养殖场放牧的18头犊牛被随机分为两组（生理盐水组[对照组]或爱泼菌素ERI组，均按1 mL/50 kg体重皮下注射一次），治疗后14天实施安乐死，以进行GIN分类计数。从对照犊牛体内检出了10种圆线虫（适应绵羊的捻转血矛线虫、环形泰勒虫、蛇形毛圆线虫、柯氏库珀线虫、巴氏细颈线虫、绵羊夏伯特线虫；适应牛的奥氏奥斯特线虫、牛库珀线虫、瑞士细颈线虫；“通用型”斧形毛圆线虫）。对照犊牛体内成年GIN的计数范围为1540至5244条，而爱泼菌素ERI治疗的犊牛体内则为0至110条。按照兽药注册技术要求国际协调会议的驱虫指南标准，即要在对照动物中证明感染程度足够，本研究表明，在接受爱泼菌素ERI治疗的动物中，绵羊夏伯特线虫、柯氏库珀线虫、捻转血矛线虫、巴氏细颈线虫、斧形毛圆线虫和蛇形毛圆线虫数量显著减少（p < 0.0001），减少幅度≥98.7%。总之，爱泼菌素ERI治疗对自然感染的幼龄牛体内一系列适应绵羊的线虫寄生虫有效。
