Li Qi, Wang Zi-Lu, Lu Huan-Xuan, Xu Yun-He
Department of Chemistry, University of Science and Technology of China, Hefei 230026, P. R. China.
Org Lett. 2022 Apr 22;24(15):2832-2836. doi: 10.1021/acs.orglett.2c00739. Epub 2022 Apr 8.
A copper-catalyzed 1,4-protosilylation of α-alkynyl-enones to form the functionalized chiral homoallenylsilanes was developed. In the presence of a chiral monopyridine oxazoline ligand, a variety of trisubstituted allene derivatives bearing a contiguous stereogenic center and axis were prepared in good yields with excellent enantioselectivities and diastereoselectivities.
开发了一种铜催化的α-炔基烯酮的1,4-原硅烷基化反应，以形成官能化的手性高烯丙基硅烷。在手性单吡啶恶唑啉配体存在下，制备了多种带有连续手性中心和轴的三取代丙二烯衍生物，产率良好，对映选择性和非对映选择性优异。
