Murdoch Children's Research Institute, Royal Children's Hospital, 50 Flemington Rd, Parkville, VIC, 3052, Australia.
Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia.
Curr Allergy Asthma Rep. 2021 Jun;22(6):61-66. doi: 10.1007/s11882-022-01032-3. Epub 2022 Apr 8.
In 2015, findings from the Learning Early About Peanut allergy (LEAP) trial provided the first convincing evidence that peanut allergy may be preventable through early peanut introduction into the infant diet. Here we discuss implementation of the LEAP study findings around the world and emerging evidence of the impacts on infant feeding and food allergy.
The LEAP findings led to rapid changes in allergy prevention guidelines internationally to recommend early peanut introduction. There is now emerging evidence that this has been followed by a substantial increase in early peanut introduction to infants. Studies investigating the impact of these changes in infant feeding practices on the prevalence of peanut allergy are underway. The LEAP trial represented a significant step forwards in food allergy prevention and new research over the past 5 years has provided insights into how best to implement this intervention in the real world.
2015 年，花生过敏预防（LEAP）研究的结果首次提供了令人信服的证据，表明通过婴儿早期食用花生可能预防花生过敏。本文讨论了 LEAP 研究结果在全球的实施情况，以及其对婴儿喂养和食物过敏的影响的新证据。
LEAP 研究结果促使国际过敏预防指南迅速发生变化，建议婴儿早期食用花生。现在有新的证据表明，婴儿早期食用花生的比例大幅增加。正在进行研究以调查这些婴儿喂养方式改变对花生过敏流行率的影响。LEAP 试验在食物过敏预防方面迈出了重要的一步，过去 5 年来的新研究深入探讨了如何在现实世界中最好地实施这一干预措施。
