Barinov E F, Statinova E A, Faber T I, Gillyer D I
Gorky Donetsk National Medical University, Donetsk, Ukraine.
Zh Nevrol Psikhiatr Im S S Korsakova. 2022;122(3):27-31. doi: 10.17116/jnevro202212203127.
In recent years, attention of experts has been attracted to remodeling of the brains' extracellular matrix in connection with analysis of alterations' causes of the blood-brain barrier (BBB), development of neuroinflammation and neovasculogenesis, as well as the possibility of regeneration of nervous tissue in cerebrovascular pathology. The review discusses the molecular mechanisms of increasing BBB permeability in stroke associated with the interaction of structural elements of the capillary wall (endothelium and pericytes), glial cells and perivascular leukocytes. The role of brain extracellular matrix remodeling in the pathogenesis of neuroinflammation and participation of pericytes in this process are discussed. Management of remodeling process of structural elements in extracellular matrix may be a promising new technology in the treatment of patients with cerebrovascular pathology.
近年来，随着对血脑屏障（BBB）改变原因的分析、神经炎症和新生血管形成的发展以及脑血管病理学中神经组织再生可能性的研究，专家们的注意力已转向大脑细胞外基质的重塑。本综述讨论了与毛细血管壁（内皮细胞和周细胞）、神经胶质细胞和血管周围白细胞的结构元件相互作用相关的中风中血脑屏障通透性增加的分子机制。还讨论了脑细胞外基质重塑在神经炎症发病机制中的作用以及周细胞在此过程中的参与情况。细胞外基质中结构元件重塑过程的管理可能是治疗脑血管疾病患者的一项有前景的新技术。
