周细胞在中风发病机制中的作用。
Roles of Pericytes in Stroke Pathogenesis.
机构信息
1 Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, GA, USA.
出版信息
Cell Transplant. 2018 Dec;27(12):1798-1808. doi: 10.1177/0963689718768455. Epub 2018 May 30.
Abstract
Stroke is a cerebrovascular disorder that affects many people worldwide. In addition to the well-established functions of astrocytes and microglia in stroke pathogenesis, pericytes also play an important role in stroke progression and recovery. As perivascular multi-potent cells and an important component of the blood-brain barrier (BBB), pericytes have been shown to exert a large variety of functions, including serving as stem/progenitor cells and maintaining BBB integrity. Here in this review, we summarize the roles of pericytes in stroke pathogenesis, with a focus on their effects in cerebral blood flow, BBB integrity, angiogenesis, immune responses, scar formation and fibrosis.
摘要
中风是一种影响全球许多人的脑血管疾病。除了星形胶质细胞和小胶质细胞在中风发病机制中的既定功能外，周细胞在中风的进展和恢复中也起着重要作用。作为血管周围多能细胞和血脑屏障 (BBB) 的重要组成部分，周细胞已被证明具有多种功能，包括作为干细胞/祖细胞和维持 BBB 的完整性。在这篇综述中，我们总结了周细胞在中风发病机制中的作用，重点介绍了它们在脑血流、BBB 完整性、血管生成、免疫反应、瘢痕形成和纤维化方面的作用。
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