[病毒感染中的细胞介导免疫]

Voiculescu C, Tăţulescu M

Rev Ig Bacteriol Virusol Parazitol Epidemiol Pneumoftiziol Bacteriol Virusol Parazitol Epidemiol. 1978 Apr-Jun;23(2):65-77.

The intervention of cellular immunity in the course of specific antiviral defence is suggested or confirmed by a series of clinical and experimental findings, i.e. the evolution of certain viral diseases following a second contact with viral antigens; discrepancy between the level of antiviral serum antibodies and the clinical course of some viral diseases; pathohistological alterations in some viral diseases, suggesting the intervention of cellular immunity; the clinical aspects of natural or experimental viral diseases in primary and secondary immunodeficiency. Investigations were likewise carried out on certain indices of cellular immunity in human or experimental viral diseases, such as delayed hypersensitivity skin tests; the transfer of immune lymphocytes; lymphocytic blastic transformation; inhibition of macrophage migration; specific cytotoxicity test. The problems concerning the role of cellular immunity in the specific defence against viruses may be grouped as follows: mechanisms of induction of the immune cellular response in viral infections; relationship between cellular and humoral immunity in antiviral resistance; relative independance of systemic and local cellular immunity in the course of viral diseases; the cellular basis of cellular mediated immunity in viral diseases.

一系列临床和实验结果表明或证实了细胞免疫在特异性抗病毒防御过程中的干预作用，即再次接触病毒抗原后某些病毒性疾病的演变；抗病毒血清抗体水平与某些病毒性疾病临床病程之间的差异；某些病毒性疾病的病理组织学改变，提示细胞免疫的干预；原发性和继发性免疫缺陷中自然或实验性病毒性疾病的临床情况。同样也对人类或实验性病毒性疾病中细胞免疫的某些指标进行了研究，如迟发型超敏皮肤试验；免疫淋巴细胞的转移；淋巴细胞母细胞转化；巨噬细胞迁移抑制；特异性细胞毒性试验。关于细胞免疫在抗病毒特异性防御中的作用问题可归纳如下：病毒感染中免疫细胞反应的诱导机制；抗病毒抵抗力中细胞免疫与体液免疫的关系；病毒性疾病过程中全身和局部细胞免疫的相对独立性；病毒性疾病中细胞介导免疫的细胞基础。