College of Pharmacy and Research Institute of Pharmaceutical Science, Gyeongsang National University, Jinju, Korea.
CNCure Biotech, Hwasun, Korea.
Nat Commun. 2022 Apr 8;13(1):1926. doi: 10.1038/s41467-022-29553-5.
Invasive aspergillosis is a critical complication in immunocompromised patients with hematologic malignancies or with viral pneumonia caused by influenza virus or SARS‑CoV‑2. Although early and accurate diagnosis of invasive aspergillosis can maximize clinical outcomes, current diagnostic methods are time-consuming and poorly sensitive. Here, we assess the ability of 2-deoxy-2-F-fluorosorbitol (F-FDS) positron emission tomography (PET) to specifically and noninvasively detect Aspergillus infections. We show that F-FDS PET can be used to visualize Aspergillus fumigatus infection of the lungs, brain, and muscles in mouse models. In particular, F-FDS can distinguish pulmonary aspergillosis from Staphylococcus aureus infection, both of which induce pulmonary infiltrates in immunocompromised patients. Thus, our results indicate that the combination of F-FDS PET and appropriate clinical information may be useful in the differential diagnosis and localization of invasive aspergillosis.
侵袭性曲霉病是血液恶性肿瘤或流感病毒或 SARS-CoV-2 引起病毒性肺炎的免疫功能低下患者的严重并发症。虽然早期和准确的诊断侵袭性曲霉病可以最大限度地提高临床结果，但目前的诊断方法耗时且灵敏度差。在这里，我们评估了 2-脱氧-2-F-氟代山梨醇（F-FDS）正电子发射断层扫描（PET）特异性和非侵入性检测曲霉属感染的能力。我们表明，F-FDS PET 可用于可视化肺部、大脑和肌肉中的烟曲霉感染的肺部、大脑和肌肉。特别是，F-FDS 可区分肺部曲霉病和金黄色葡萄球菌感染，两者均会在免疫功能低下的患者中引起肺部浸润。因此，我们的结果表明，F-FDS PET 与适当的临床信息相结合可能有助于侵袭性曲霉病的鉴别诊断和定位。
