形态发生中的膜-肌动蛋白相互作用：从 Drosophila 细胞化中得到的启示。
Membrane-actin interactions in morphogenesis: Lessons learned from Drosophila cellularization.
机构信息
Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA; Graduate Program in Integrative and Molecular Biomedical Sciences, Baylor College of Medicine, Houston, TX 77030, USA.
Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA; Graduate Program in Integrative and Molecular Biomedical Sciences, Baylor College of Medicine, Houston, TX 77030, USA.
出版信息
Semin Cell Dev Biol. 2023 Jan 15;133:107-122. doi: 10.1016/j.semcdb.2022.03.028. Epub 2022 Apr 5.
Abstract
During morphogenesis, changes in the shapes of individual cells are harnessed to mold an entire tissue. These changes in cell shapes require the coupled remodeling of the plasma membrane and underlying actin cytoskeleton. In this review, we highlight cellularization of the Drosophila embryo as a model system to uncover principles of how membrane and actin dynamics are co-regulated in space and time to drive morphogenesis.
摘要
在形态发生过程中，个体细胞形状的变化被用来塑造整个组织。这些细胞形状的变化需要质膜和下面的肌动蛋白细胞骨架的偶联重塑。在这篇综述中，我们强调了果蝇胚胎的细胞化作为一个模型系统，以揭示膜和肌动蛋白动力学如何在空间和时间上被共同调控以驱动形态发生的原理。
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