Nizankowska E, Czerniawska-Mysik G, Szczeklik A
Eur J Respir Dis. 1986 Nov;69(5):363-8.
Inhibition of prostacyclin biosynthesis by aspirin might be expected to promote asthmatic attacks in aspirin-intolerant patients. In vitro, prostacyclin impedes generation of leukotrienes and opposes their bronchoconstrictive action. In a double-blind study we compared the effects of intravenous infusions of prostacyclin with those of its solvent on bronchoconstriction provoked by threshold doses of aspirin in nine known aspirin-sensitive asthmatics. The intensity of bronchial obstruction precipitated by aspirin was similar during prostacyclin and placebo infusions. There was no difference in other symptoms of intolerance, except for rhinorrhea which seemed accentuated by prostacyclin (possibly because of nasal vasodilatation). Our results suggest that either the inhibitory effects of prostacyclin on leukotrienes described in vitro do not apply in vivo, or the importance of leukotrienes has been overestimated in this type of asthma.
阿司匹林对前列环素生物合成的抑制作用可能会引发阿司匹林不耐受患者的哮喘发作。在体外实验中，前列环素会抑制白三烯的生成并对抗其支气管收缩作用。在一项双盲研究中，我们比较了静脉输注前列环素及其溶剂对9名已知对阿司匹林敏感的哮喘患者因阈剂量阿司匹林引发的支气管收缩的影响。在输注前列环素和安慰剂期间，阿司匹林引发的支气管阻塞强度相似。除了流涕似乎因前列环素而加重（可能是由于鼻血管扩张）外，其他不耐受症状并无差异。我们的研究结果表明，要么前列环素在体外对白三烯的抑制作用在体内并不适用，要么在这类哮喘中白三烯的重要性被高估了。
