Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-Ku, Okayama, 700-8558, Japan.
Department of Pharmacy, Okayama University Hospital, Okayama, 700-8558, Japan.
Sci Rep. 2022 Apr 8;12(1):5921. doi: 10.1038/s41598-022-09946-8.
To promote antimicrobial stewardship, we studied antimicrobial prescription rates for uncomplicated cystitis, a common outpatient disease requiring antibiotic treatment. This multicenter retrospective study was performed from January 1, 2018, to December 31, 2020, in Japan, targeting outpatients aged ≥ 20 years whose medical records revealed International Classification of Diseases (ICD-10) codes suggesting uncomplicated cystitis (N300). The data of 1445 patients were collected and that of 902 patients were analyzed. The overall median patient age was 71 years and a proportion of those aged less than 50 years was 18.8% with a female dominance (82.6%). Antimicrobials were prescribed for 884 patients (98.0%) and a total of 623 patients (69.1%) were treated with broad-spectrum drugs, including fluoroquinolones (36.0%), third-generation cephalosporins (29.9%) and faropenem (3.1%). A logistic regression model revealed that the broad-spectrum agents were significantly prescribed for the older patients, male patients, and those who visited internists. Recurrence was observed in 37 (4.1%) cases, and the multivariate analysis suggested any of age, sex, or antimicrobial types were not associated with the recurrence. Collectively, approximately two-thirds of antimicrobials prescribed for uncomplicated cystitis were broad-spectrum agents. The present data would be an indicator for antimicrobial prescriptions in uncomplicated cystitis in Japan.
为了促进抗菌药物管理，我们研究了单纯性膀胱炎（一种常见的需要抗生素治疗的门诊疾病）的抗菌药物处方率。这项多中心回顾性研究于 2018 年 1 月 1 日至 2020 年 12 月 31 日在日本进行，针对的是年龄≥20 岁的门诊患者，其病历中显示国际疾病分类（ICD-10）编码提示单纯性膀胱炎（N300）。共收集了 1445 名患者的数据，其中 902 名患者的数据进行了分析。患者的总体中位年龄为 71 岁，年龄小于 50 岁的患者比例为 18.8%，且女性居多（82.6%）。884 名患者（98.0%）开具了抗菌药物处方，共有 623 名患者（69.1%）使用了广谱药物，包括氟喹诺酮类（36.0%）、第三代头孢菌素类（29.9%）和法罗培南（3.1%）。逻辑回归模型显示，广谱药物主要用于老年患者、男性患者和内科医生就诊的患者。37 例（4.1%）患者出现复发，多变量分析提示年龄、性别或抗菌药物类型与复发均无相关性。总的来说，大约三分之二用于单纯性膀胱炎的抗菌药物是广谱药物。本研究数据将为日本单纯性膀胱炎的抗菌药物处方提供参考。
