Zawalich W S, Diaz V A
Diabetes. 1987 Jan;36(1):118-22. doi: 10.2337/diab.36.1.118.
Prior, short-term exposure of isolated perifused islets to cholecystokinin (CCK8S) sensitizes them to subsequent glucose stimulation. This sensitization effect develops quickly and persists long after the removal of CCK8S from the perifusion medium. Continued binding of CCK8S to its receptor on the beta-cell and the increase in glucose metabolism noted with glucose stimulation are essential for the full expression of this response. This sensitization process may play an integral role in the postulated incretin effect of the peptide.
先前，将分离的经灌注的胰岛短期暴露于胆囊收缩素（CCK8S）会使其对随后的葡萄糖刺激敏感。这种致敏作用发展迅速，并且在从灌注培养基中去除CCK8S后仍会持续很长时间。CCK8S持续与其在β细胞上的受体结合以及葡萄糖刺激时所观察到的葡萄糖代谢增加，对于充分表达这种反应至关重要。这种致敏过程可能在该肽假定的肠促胰岛素效应中发挥不可或缺的作用。
