Wright P D, Holdsworth J D, Dionigi P, Clague M B, James O F
Gut. 1986 Nov;27 Suppl 1(Suppl 1):96-102. doi: 10.1136/gut.27.suppl_1.96.
Thirty seven patients with established cirrhosis of the liver were subjected to measurement of body protein metabolism using L-(1-14C) labelled leucine as a tracer. The effects of disease severity and those of solutions containing 0%, 16%, 35%, 53%, and 100% branched chain amino acids were evaluated. Significant increases in protein synthesis were noted with solutions containing 35%, 53%, and 100% branched chain amino acids, but in patients receiving 100% branched chain amino acids without additional essential amino acid supplement the increase in synthesis was matched by a significant increase in protein breakdown. Protein balance was thus improved only in patients receiving 35% and 53% branched chain amino acids. It was concluded that the high increase in protein breakdown in patients receiving 100% branched chain amino acids was undesirable, and such a solution should not be recommended for clinical use.
37例确诊为肝硬化的患者使用L-(1-¹⁴C)标记的亮氨酸作为示踪剂进行了机体蛋白质代谢测定。评估了疾病严重程度以及含0%、16%、35%、53%和100%支链氨基酸溶液的影响。含35%、53%和100%支链氨基酸的溶液可使蛋白质合成显著增加，但在接受100%支链氨基酸且未额外补充必需氨基酸的患者中，合成增加的同时蛋白质分解也显著增加。因此，只有接受35%和53%支链氨基酸的患者蛋白质平衡得到改善。得出的结论是，接受100%支链氨基酸的患者蛋白质分解大幅增加是不可取的，不应推荐这种溶液用于临床。
