Bhimji S, Godin D V, McNeill J H
Horm Metab Res. 1986 Nov;18(11):734-8. doi: 10.1055/s-2007-1012422.
Epidemiological evidence suggests that magnesium deficiency may be a factor in the etiology of cardiovascular disease. In the present study, magnesium status was assessed in rabbits 10 weeks following the administration of a diabetogenic dose of alloxan which resulted in significant hyperglycemia and hypoinsulinemia. Decreased erythrocyte magnesium levels were apparent after 6-8 weeks, although no corresponding changes in the magnesium concentration of plasma were apparent. Depletion of magnesium was also observed in left ventricle, spleen, lung, pancreas and aorta. Insulin treatment (for 4 weeks) after 6 weeks of diabetes, prevented the magnesium depletion in both the tissues and red blood cells. Our results provide evidence for alterations in magnesium handling in an experimental model of chronic diabetes.
流行病学证据表明，镁缺乏可能是心血管疾病病因中的一个因素。在本研究中，给兔子注射致糖尿病剂量的四氧嘧啶10周后评估其镁状态，该剂量导致了显著的高血糖和低胰岛素血症。6 - 8周后红细胞镁水平明显降低，尽管血浆镁浓度没有相应变化。在左心室、脾脏、肺、胰腺和主动脉中也观察到镁的耗竭。糖尿病6周后进行胰岛素治疗（持续4周），可防止组织和红细胞中的镁耗竭。我们的结果为慢性糖尿病实验模型中镁代谢的改变提供了证据。
