HBV 和 HCV 合并感染患者中 HCV 病毒血症对 HBV 生物标志物的影响。

Impact of HCV viremia on HBV biomarkers in patients coinfected with HBV and HCV.

机构信息

Department of Internal Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, No 2, Ming-Shen Road, Dalin Town, Chia-Yi County, 622, Taiwan.

School of Medicine, Tzuchi University, Hualien, Taiwan.

出版信息

BMC Infect Dis. 2022 Apr 9;22(1):351. doi: 10.1186/s12879-022-07326-1.

DOI:10.1186/s12879-022-07326-1

PMID:35397497

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8994285/

Abstract

BACKGROUNDS

Hepatitis B virus (HBV) biomarkers reflect the status of HBV infection; however, their role in patients with chronic hepatitis B and C (HBV/HCV) coinfection remains unknown. This study evaluated the characteristics of HBV biomarkers in patients with chronic HBV/HCV coinfection.

METHODS

One hundred untreated HBV/HCV coinfected patients were enrolled. Active viral infection was defined as viral load above 2000 U/L and 15 U/L for HBV and HCV, respectively. Blood samples were analyzed for HBV biomarkers, including hepatitis B surface antigen (HBsAg), hepatitis B core-related antigen (HBcrAg), HBV DNA, and HBV pregenomic RNA (HBV pgRNA). The impact of HCV viremia was also studied.

RESULTS

A total of 15 patients were HBV-inactive/HCV-inactive, 63 patients were HBV-inactive/HCV-active, 14 patients were HBV-active/HCV-inactive and 8 patients were HBV-active/HCV-active. A total of 71 (71%) patients were active HCV and 22 (22%) were active HBV. HBsAg, HBcrAg, and HBV DNA correlated with each other (P < 0.001). HBV pgRNA displayed no correlations with HBV DNA, HBsAg, or HBcrAg. Patients with HCV viremia had significantly lower HBV DNA, HBsAg, and HBcrAg levels as well as higher HBV pgRNA levels and lower HBV DNA:pgRNA ratio than those without viremia (HBV DNA, P < 0.001; HBsAg, P = 0.015; HBcrAg, P = 0.006; HBV pgRNA, P = 0.073; and HBV DNA:pgRNA ratio, P < 0.001).

CONCLUSIONS

In patients coinfected with HBV and HCV, HBsAg, HBcrAg, and HBV DNA significantly correlated with each other. HBV and HCV coinfected patients with HCV viremia have lower HBV DNA, HBsAg, HBcrAg, and HBV DNA:pgRNA ratio as well as higher HBV pgRNA levels.

摘要

背景

乙型肝炎病毒 (HBV) 标志物反映 HBV 感染状况；然而，它们在慢性乙型肝炎和丙型肝炎 (HBV/HCV) 合并感染患者中的作用尚不清楚。本研究评估了慢性 HBV/HCV 合并感染患者中 HBV 标志物的特征。

方法

纳入了 100 例未经治疗的 HBV/HCV 合并感染患者。病毒载量超过 2000 U/L 和 15 U/L 分别定义为 HBV 和 HCV 的活动性病毒感染。分析了乙型肝炎表面抗原 (HBsAg)、乙型肝炎核心相关抗原 (HBcrAg)、HBV DNA 和 HBV 前基因组 RNA (HBV pgRNA) 等 HBV 标志物。还研究了 HCV 病毒血症的影响。

结果

共有 15 例患者 HBV 无活性/HCV 无活性，63 例患者 HBV 无活性/HCV 有活性，14 例患者 HBV 有活性/HCV 无活性，8 例患者 HBV 有活性/HCV 有活性。共有 71 例 (71%) 患者 HCV 病毒血症活跃，22 例 (22%) 患者 HBV 病毒血症活跃。HBsAg、HBcrAg 和 HBV DNA 相互关联 (P < 0.001)。HBV pgRNA 与 HBV DNA、HBsAg 或 HBcrAg 无相关性。有 HCV 病毒血症的患者 HBV DNA、HBsAg 和 HBcrAg 水平明显较低，HBV pgRNA 水平较高，HBV DNA:pgRNA 比值较低，而无病毒血症的患者则相反 (HBV DNA，P < 0.001；HBsAg，P = 0.015；HBcrAg，P = 0.006；HBV pgRNA，P = 0.073；HBV DNA:pgRNA 比值，P < 0.001)。